ReviewThe oncologist2013
Nutrient restriction and radiation therapy for cancer treatment: when less is more.
Review in The oncologist, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- Targeting metabolism with a ketogenic diet during the treatment of glioblastoma multiforme.Journal of neuro-oncology · 2014Trial
- Nutrition as Modulator of Oxidative Stress in Cancer Prevention and Treatment.International journal of molecular sciences · 2026Review
- Review
- Fasting mimicking diet during neo-adjuvant chemotherapy in breast cancer patients: a randomized controlled trial study.Frontiers in nutrition · 2024Article
- Article
- Bioelectric Fields at the Beginnings of Life.Bioelectricity · 2022Review
- Molecular Mechanisms for Ketone Body Metabolism, Signaling Functions, and Therapeutic Potential in Cancer.Nutrients · 2022Review
- Review
- Intermittent fasting during adjuvant chemotherapy may promote differential stress resistance in breast cancer patients.Journal of the Egyptian National Cancer Institute · 2022Article
- Chronoradiobiology of Breast Cancer: The Time Is Now to Link Circadian Rhythm and Radiation Biology.International journal of molecular sciences · 2022Review
- High ATP Production Fuels Cancer Drug Resistance and Metastasis: Implications for Mitochondrial ATP Depletion Therapy.Frontiers in oncology · 2021Review
- Fasting to enhance Cancer treatment in models: the next steps.Journal of biomedical science · 2020Review
- The Impact of Serum Glucose in the Treatment of Locoregionally Advanced Pancreatic Cancer.American journal of clinical oncology · 2019Article
- Nutrient Deprivation Modulates the Metastatic Potential of Breast Cancer Cells.Reports of biochemistry & molecular biology · 2019Article
- Caloric restriction is associated with preservation of muscle strength in experimental cancer cachexia.Aging · 2018Article
- Onco-metabolism: defining the prognostic significance of obesity and diabetes in women with brain metastases from breast cancer.Breast cancer research and treatment · 2018Article
- The Impact of Serum Glucose, Anti-Diabetic Agents, and Statin Usage in Non-small Cell Lung Cancer Patients Treated With Definitive Chemoradiation.Frontiers in oncology · 2018Article
- Rationale, Feasibility and Acceptability of Ketogenic Diet for Cancer Treatment.Journal of cancer prevention · 2017Review
- Dietary restriction: could it be considered as speed bump on tumor progression road?Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Fortifying the Treatment of Prostate Cancer with Physical Activity.Prostate cancer · 2016Review
Corrections and comments
- Commented on by
- Commented on byIn reply.2013
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Calorie restriction (CR), or a diet modification aiming to reduce the total intake of calories by 20%-40%, has been shown to increase longevity across multiple species. Recently, there has been growing interest in investigating the potential role of CR as a treatment intervention for age-related diseases, such as cancer, because an increasing body of literature has demonstrated a metabolic component to both carcinogenesis and tumor progression. In fact, many of the molecular pathways that are altered with CR are also known to be altered in cancer. Therefore, manipulation of these pathways using CR can render cancer cells, and most notably breast cancer cells, more susceptible to standard cytotoxic treatment with radiation and chemotherapy. In this review article we demonstrate the laboratory and clinical evidence that exists for CR and show compelling evidence through the molecular pathways CR induces about how it may be used as a treatment in tandem with radiation therapy to improve our rates of disease control.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.