ArticleJournal of neurology2013
Clinical determinants of primary and secondary fatigue in patients with Parkinson's disease.
Article in Journal of neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Poor sleep quality among patients with Parkinson's disease: a meta-analysis and systematic review.Frontiers in psychiatry · 2025Pooled it
- Acupuncture in the treatment of fatigue in Parkinson's disease: A pilot, randomized, controlled, study.Brain and behavior · 2018Trial
- Review
- Renshen Yangrong decoction for secondary malaise and fatigue: network pharmacology and Mendelian randomization study.Frontiers in nutrition · 2024Article
- Fatigue in fluctuating Parkinson's disease patients: possible impact of safinamide.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- Demographic Influences on the Relationship Between Fatigue and Quality of Life in Parkinson's Disease.Movement disorders clinical practice · 2022Article
- Understanding fatigue in progressive supranuclear palsy.Scientific reports · 2021Article
- Article
- Acupuncture in the treatment of fatigue in Parkinson's disease: A protocol for systematic review and meta-analysis.Medicine · 2020Article
- Supplementary motor area functional connectivity in "drug-naïve" Parkinson's disease patients with fatigue.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- The role of dispositional mindfulness in a stress-health pathway among Parkinson's disease patients and caregiving partners.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Article
- Fatigue evaluated using the 16-item Parkinson Fatigue Scale (PFS-16) predicts Parkinson's disease prognosis.Fujita medical journal · 2019Article
- Review
- Risk Factors of Fatigue in Idiopathic Parkinson's Disease in a Polish Population.Parkinson's disease · 2016Article
- The Pathophysiology of Fatigue in Parkinson's Disease and its Pragmatic Management.Movement disorders clinical practiceReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical and psychosocial factors associated separately with primary and secondary fatigue in Parkinson's disease (PD) patients have not been thoroughly studied before. The aim of our study was to assess factors associated with different fatigue domains in groups with primary and secondary fatigue in PD separately. We divided 165 non-demented PD patients according to the absence/presence of depression, anxiety and excessive somnolence into groups with primary fatigue (N = 63) and with secondary fatigue (N = 102). Fatigue domains examined using the multidimensional fatigue inventory were associated through multiple linear regression analyses for each group separately with sociodemographic data, disease duration, functional status as assessed by the Unified Parkinson's Disease Rating Scale, treatment, depression, anxiety, excessive somnolence and sleep quality. Out of the assessed non-motor symptoms, fatigue was the most frequent (77.6%). The prevalence of fatigue in the secondary fatigue group was significantly higher than in the primary fatigue group. Both fatigue groups differed significantly in factors associated with different fatigue domains. Functional status or other disease-related factors were not associated with primary fatigue. In the secondary fatigue group, we found associations between some fatigue domains and functional status, older age, male gender and higher anxiety scores. To our knowledge, this is the first study to separately describe clinical determinants and psychosocial factors associated with different fatigue domains in primary and secondary fatigue in PD, underlining the importance of distinguishing primary and secondary fatigue in future PD studies and clinical practice.
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