ArticleMolecules (Basel, Switzerland)2013
Synthesis and in vitro antiproliferative activity of new phenylaminoisoquinolinequinones against cancer cell lines.
Article in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Targeting Cancer Cell Proliferation Using Piperazine-Linked Quinolinequinones: Mechanism and Metabolic Profile.Chemical biology & drug design · 2025Article
- Discovery of Potent IsoquinolinequinoneJournal of medicinal chemistry · 2024Article
- Green Synthesis and Electrochemical Properties of Mono- and Dimers Derived from Phenylaminoisoquinolinequinones.Molecules (Basel, Switzerland) · 2019Article
- Preparation of Novel Homodimers Derived from Cytotoxic Isoquinolinequinones. A Twin Drug Approach.Molecules (Basel, Switzerland) · 2018Article
- Synthesis, half-wave potentials and antiproliferative activity of 1-aryl-substituted aminoisoquinolinequinones.Molecules (Basel, Switzerland) · 2014Article
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Authors and funding
5 authors.
Funding
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Abstract
A variety of phenylaminoisoquinolinequinones were synthesized and tested for their antiproliferative activity against three human-tumor derived cancer cell lines. The new aminoquinones were prepared from 4-methoxycarbonyl-3-methylisoquinoline-5,8-quinone (1) via acid-induced amination and bromination reactions. Remarkable differences in antiproliferative activity were observed depending upon the location and donor capacity of the substituted phenylamino group at the quinone nucleus. The effect of the substituents on the biological activity is discussed in terms of the donor-acceptor interactions which were evaluated through the redox properties of the aminoquinones.
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