ArticleThe Journal of pathology2013
Of mice and men: the riddle of tubular regeneration.
Article in The Journal of pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Kidney Cells Regeneration: Dedifferentiation of Tubular Epithelium, Resident Stem Cells and Possible Niches for Renal Progenitors.International journal of molecular sciences · 2019Review
- Urinary nephrospheres indicate recovery from acute kidney injury in renal allograft recipients - a pilot study.BMC nephrology · 2019Article
- Urinary neprilysin in the critically ill patient.BMC nephrology · 2017Article
- A population of mitochondrion-rich cells in the pars recta of mouse kidney.Cell and tissue research · 2016Article
- Insights into kidney stem cell development and regeneration using zebrafish.World journal of stem cells · 2016Review
- Who regenerates the kidney tubule?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2015Review
- Renal progenitors and childhood: from development to disorders.Pediatric nephrology (Berlin, Germany) · 2014Review
- Controversies on the origin of proliferating epithelial cells after kidney injury.Pediatric nephrology (Berlin, Germany) · 2014Review
- New tides: using zebrafish to study renal regeneration.Translational research : the journal of laboratory and clinical medicine · 2014Review
- Differentiated kidney epithelial cells repair injured proximal tubule.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Kidney injury, stem cells and regeneration.Current opinion in nephrology and hypertension · 2014Review
- Stem cells: potential and challenges for kidney repair.American journal of physiology. Renal physiology · 2014Review
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regeneration can occur through multiple distinct mechanisms, such as pluripotent stem cells, lineage-committed progenitors or dedifferentiation. The respective contribution of each of these regenerative strategies in every organ or tissue may be different. Recent results indicate that dedifferentiation contributes less than previously thought, and that stem or progenitor cells seem to be the main drivers of regenerative processes. Our views of regeneration in the kidney are undergoing the same process of revision. Indeed, studies in humans have established the existence of a scattered population of tubular progenitors in the adult kidney. Renal progenitors have been discovered also in other animal classes such as fish and insects. In contrast, in rodents a tubular progenitor phenotype seems to be induced only after tubular injury, suggesting some differences may exist. Is this difference really related to a distinct regenerative strategy or is it simply a matter of the type and modality of cellular markers expressed? It may also be possible that progenitor cells, as well as tubular cell dedifferentiation, act in concert to allow regeneration of a complex organ like the adult mammalian kidney, as recently proposed also for the liver. Further studies are needed to resolve the riddle of tubular regeneration. However, beyond the controversial results obtained from humans and rodents, identification of tubular progenitors in humans can move the field forward and provide a novel perspective for understanding tubular regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.