ArticleInvestigative ophthalmology & visual science2013
Inner retinal oxygen extraction fraction in rat.
Article in Investigative ophthalmology & visual science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Retinal Hypoxia: Relation to Blood Flow and Oxygen Metabolic Biomarkers.Investigative ophthalmology & visual science · 2026Article
- Quantifying retinal oxygenation and metabolism by phosphorescence lifetime imaging.Experimental eye research · 2025Review
- Multimodal retinal imaging by visible light optical coherence tomography and phosphorescence lifetime ophthalmoscopy in the mouse eye.Neurophotonics · 2025Article
- Retinal Vessel Flicker Light Responsiveness and Its Relation to Analysis Protocols and Static and Metabolic Data in Healthy Subjects.Biomedicines · 2025Article
- Metabolic blood flow regulation in a hybrid model of the human retinal microcirculation.Mathematical biosciences · 2023Article
- Characterization of Oxygen Nanobubbles and In Vitro Evaluation of Retinal Cells in Hypoxia.Translational vision science & technology · 2023Article
- Assessment of retinal oxygen metabolism, visual function, thickness and degeneration markers after variable ischemia/reperfusion in rats.Experimental eye research · 2021Article
- Article
- Retinal Oxygen Delivery, Metabolism, and Extraction Fraction during Long-Term Bilateral Common Carotid Artery Occlusion in Rats.Scientific reports · 2020Article
- Retinal Oxygen Delivery, Metabolism and Extraction Fraction and Retinal Thickness Immediately Following an Interval of Ophthalmic Vessel Occlusion in Rats.Scientific reports · 2019Article
- A Model for Graded Retinal Ischemia in Rats.Translational vision science & technology · 2018Article
- Retinal Oxygen Delivery and Metabolism in Healthy and Sickle Cell Retinopathy Subjects.Investigative ophthalmology & visual science · 2018Article
- Retinal Vascular and Oxygen Temporal Dynamic Responses to Light Flicker in Humans.Investigative ophthalmology & visual science · 2017Article
- Retinal Oximetry and Vessel Diameter Measurements With a Commercially Available Scanning Laser Ophthalmoscope in Diabetic Retinopathy.Investigative ophthalmology & visual science · 2017Article
- A Method for Combined Retinal Vascular and Tissue Oxygen Tension Imaging.Scientific reports · 2017Article
- In vivo retinal and choroidal hypoxia imaging using a novel activatable hypoxia-selective near-infrared fluorescent probe.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2016Article
- Inner Retinal Oxygen Delivery, Metabolism, and Extraction Fraction in Ins2Akita Diabetic Mice.Investigative ophthalmology & visual science · 2016Article
- Inner Retinal Oxygen Extraction Fraction in Response to Light Flicker Stimulation in Humans.Investigative ophthalmology & visual science · 2015Article
- Response of inner retinal oxygen extraction fraction to light flicker under normoxia and hypoxia in rat.Investigative ophthalmology & visual science · 2014Article
- In vivo retinal vascular oxygen tension imaging and fluorescein angiography in the mouse model of oxygen-induced retinopathy.Investigative ophthalmology & visual science · 2013Article
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Authors and funding
4 authors.
Funding
Abstract
purposeOxygen extraction fraction (OEF), defined by the ratio of oxygen consumption to delivery, may be a useful parameter for assessing the retinal tissue status under impaired circulation. We report a method for measurement of inner retinal OEF in rats under normoxia and hypoxia based on vascular oxygen tension (PO(2)) imaging.
methodsRetinal vascular PO(2) measurements were obtained in 10 rats, using our previously developed optical section phosphorescence lifetime imaging system. Inner retinal OEF was derived from retinal vascular PO(2) measurements based on Fick's principle. Measurements of inner retinal OEF obtained under normoxia were compared between nasal and temporal retinal sectors and repeatability was determined. Inner retinal OEF measurements obtained under normoxia and hypoxia were compared.
resultsRetinal vascular PO(2) and inner retinal OEF measurements were repeatable (ICC ≥ 0.83). Inner retinal OEF measurements at nasal and temporal retinal sectors were correlated (R = 0.71; P = 0.02; n = 10). Under hypoxia, both retinal arterial and venous PO(2) decreased significantly as compared with normoxia (P < 0.001; n = 10). Inner retinal OEF was 0.46 ± 0.13 under normoxia and increased significantly to 0.67 ± 0.16 under hypoxia (mean ± SD; P < 0.001; n = 10).
conclusionsInner retinal OEF is a promising quantitative biomarker for the adequacy of oxygen supply for metabolism under physiologically and pathologically altered conditions.
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