ArticlePlant signaling & behavior2013
Ascorbate oxidase is the potential conductor of a symphony of signaling pathways.
Article in Plant signaling & behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 95 citations in OpenAlex.
- Exploring the genetic landscape of sesame: whole genome sequencing reveals distinct Egyptian lineages and SNP variability.Molecular genetics and genomics : MGG · 2026Article
- Involvement of ascorbate oxidase in the regulation of the leaf development mediated by mepiquat chloride in cotton seedlings.Frontiers in plant science · 2026Article
- A genome-wide analysis of ascorbate oxidase gene family and hormonal activity in mango exposed to enhanced UV-B radiation.BMC plant biology · 2025Article
- 3D printing approaches to simulate natural diets for insects with implications for domestication and mass-rearing.Frontiers in insect science · 2025Review
- Transcriptome analysis of resistant and susceptible Medicago truncatula genotypes in response to spring black stem and leaf spot disease.BMC plant biology · 2024Article
- Revisiting the role of ascorbate oxidase in plant systems.Journal of experimental botany · 2024Review
- Deciphering the Genomic Characterization of the GGP Gene Family and Expression Verification ofAntioxidants (Basel, Switzerland) · 2024Article
- Growth, Physiological, and Biochemical Variations in Tomatoes after Infection with Different Density Levels ofPlants (Basel, Switzerland) · 2024Article
- Article
- Effects of endophytes on early growth and ascorbate metabolism inFrontiers in plant science · 2024Article
- Redox dynamics in seeds ofFrontiers in plant science · 2024Article
- Fungal Laccases: Fundamentals, Engineering and Classification Update.Biomolecules · 2023Review
- OsJAB1 Positively Regulates Ascorbate Biosynthesis and Negatively Regulates Salt Tolerance Due to Inhibiting Early-Stage Salt-Induced ROS Accumulation in Rice.Plants (Basel, Switzerland) · 2023Article
- Salt Stress-Induced Modulation of Porphyrin Biosynthesis, Photoprotection, and Antioxidant Properties in Rice Plants (Antioxidants (Basel, Switzerland) · 2023Article
- Characteristic of the Ascorbate Oxidase Gene Family inInternational journal of molecular sciences · 2022Article
- Nanoforms of essential metals: from hormetic phytoeffects to agricultural potential.Journal of experimental botany · 2022Review
- Quantitative redox proteomics revealed molecular mechanisms of salt tolerance in the roots of sugar beet monomeric addition line M14.Botanical studies · 2022Article
- The perils of planning strategies to increase vitamin C content in plants: Beyond the hype.Frontiers in plant science · 2022Review
- Insight into the regulatory networks underlying the high lipid perennial ryegrass growth under different irradiances.PloS one · 2022Article
- Regulation of Vitamin C Accumulation for Improved Tomato Fruit Quality and Alleviation of Abiotic Stress.Genes · 2021Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The functional role of ascorbate oxidase (AO; EC 1.10.3.3) has never been fully explained so far, due to the difficulties in understanding the presence of an enzyme specifically oxidizing ascorbate with no obvious advantage, and the apparent disadvantage of lowering plant stress resistance as a consequence of ascorbate consumption. Here we suggest a complete change of perspective, by proposing an essential role of AO as a modulator of both ascorbate and oxygen content, with relevant implications related to signaling. By affecting the overall redox state, AO is actually involved in redox regulation in the extracellular matrix. In addition, AO can contribute to creating a hypoxic microenvironment, especially relevant in the maintenance of meristem identity and the establishment of mutualistic plant-microbe interactions. We also hypothesize the possible involvement of AO in the activation of a signaling cascade analogous to the mechanism of prolyl hydroxylases/Hypoxia Inducible Factors in animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.