ReviewPlant signaling & behavior2013
The function of the Mediator complex in plant immunity.
Review in Plant signaling & behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed.
- The Mediator complex: co-transcriptional regulation and beyond.RNA biology · 2026Review
- Integrated Phylogenomics and Expression Profiling of the MED Gene Family inPlants (Basel, Switzerland) · 2026Article
- PsAvh109 suppresses SA-triggered immunity by mimicking TPL function to disrupt mediator complex assembly.Nature communications · 2026Article
- Genome-wide association study of water-use efficiency and shoot biomass conferred by V. berlandieri rootstocks in grapevine.BMC plant biology · 2026Article
- The CBP60b-14-3-3 functional module regulates immunity in arabidopsis.Frontiers in plant science · 2026Article
- Candidate genes for anthracnose resistance in Senegalese sorghum: a machine learning-based exploration.Functional & integrative genomics · 2025Article
- Humic Substances from Different Sources Modulate Salicylic Acid-Mediated Defense in Plants Infected by Powdery Mildew.Plants (Basel, Switzerland) · 2025Article
- Natural expression variation for the ArabidopsisFrontiers in plant science · 2025Article
- Arabidopsis MORC1 and MED9 Interact to Regulate Defense Gene Expression and Plant Fitness.The plant pathology journal · 2024Article
- Insights into the early transcriptomic response against watermelon mosaic virus in melon.BMC plant biology · 2024Article
- New Insights into Hop Latent Viroid Detection, Infectivity, Host Range, and Transmission.Viruses · 2023Article
- Comprehensive Transcriptome Analysis Reveals Genome-Wide Changes Associated with Endoplasmic Reticulum (ER) Stress in Potato (International journal of molecular sciences · 2022Article
- The Mediator Complex: A Central Coordinator of Plant Adaptive Responses to Environmental Stresses.International journal of molecular sciences · 2022Review
- HopA1 Effector fromInternational journal of molecular sciences · 2021Article
- ORN: Inferring patient-specific dysregulation status of pathway modules in cancer with OR-gate Network.PLoS computational biology · 2021Article
- Roles of Endogenous Melatonin in Resistance toFrontiers in plant science · 2021Article
- Arabidopsis MED18 Interaction With RNA Pol IV and V Subunit NRPD2a in Transcriptional Regulation of Plant Immune Responses.Frontiers in plant science · 2021Article
- Mediator Complex: A Pivotal Regulator of ABA Signaling Pathway and Abiotic Stress Response in Plants.International journal of molecular sciences · 2020Review
- Mapping the Gene Expression Spectrum of Mediator Subunits in Response to Viroid Infection in Plants.International journal of molecular sciences · 2020Article
- Stem rust resistance in wheat is suppressed by a subunit of the mediator complex.Nature communications · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Upon pathogen infection, plants undergo dramatic transcriptome reprogramming to shift from normal growth and development to immune response. During this rapid process, the multiprotein Mediator complex has been recognized as an important player to fine-tune gene-specific and pathway-specific transcriptional reprogramming by acting as an adaptor/coregulator between sequence-specific transcription factor and RNA polymerase II (RNAPII). Here, we review current understanding of the role of five functionally characterized Mediator subunits (MED8, MED15, MED16, MED21 and MED25) in plant immunity. All these Mediator subunits positively regulate resistance against leaf-infecting biotrophic bacteria or necrotrophic fungi. While MED21 appears to regulate defense against fungal pathogens via relaying signals from upstream regulators and chromatin modification to RNAPII, the other four Mediator subunits locate at different positions of the defense network to convey phytohormone signal(s). Fully understanding the role of Mediator in plant immunity needs to characterize more Mediator subunits in both Arabidopsis and other plant species. Identification of interacting proteins of Mediator subunits will further help to reveal their specific regulatory mechanisms in plant immunity.
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