SynthesisJournal of exposure science & environmental epidemiology
Is urinary 1-hydroxypyrene a valid biomarker for exposure to air pollution in outdoor workers? A meta-analysis.
Synthesis in Journal of exposure science & environmental epidemiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- Associations Between Urinary Metabolites of Polycyclic Aromatic Hydrocarbons and Liver Enzyme Levels Among Korean Firefighters.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2025Article
- Associations Between Individual Health Risk Perceptions and Biomarkers of PAH Exposure Before and After PMToxics · 2025Article
- Immune-mediated disease caused by climate change-associated environmental hazards: mitigation and adaptation.Frontiers in science · 2024Article
- Non-carcinogenic and cumulative risk assessment of exposure of kitchen workers in restaurants and local residents in the vicinity of polycyclic aromatic hydrocarbons.Scientific reports · 2023Article
- Exposure to polycyclic aromatic hydrocarbon-induced oxidative stress in individuals living near restaurants: a cross-sectional study in Shiraz, Iran.Environmental monitoring and assessment · 2022Article
- Prenatal urinary metabolites of polycyclic aromatic hydrocarbons and toddler cognition, language, and behavior.Environment international · 2022Article
- The association between the urinary biomarkers of polycyclic aromatic hydrocarbons and risk of metabolic syndromes and blood cell levels in adults in a Middle Eastern area.Journal of environmental health science & engineering · 2021Article
- Article
- Filaggrin Polymorphisms and the Uptake of Chemicals through the Skin-A Human Experimental Study.Environmental health perspectives · 2021Article
- Elevated exposure to polycyclic aromatic hydrocarbons (PAHs) may trigger cancers in Pakistan: an environmental, occupational, and genetic perspective.Environmental science and pollution research international · 2020Review
- Air pollution and telomere length: a systematic review of 12,058 subjects.Cardiovascular diagnosis and therapy · 2018Article
- Are metals and pyrene levels additional factors playing a pivotal role in air pollution-induced inflammation in taxi drivers?Toxicology research · 2018Article
- Levels of 1-hydroxypyrene in urine of people living in an oil producing region of the Andean Amazon (Ecuador and Peru).International archives of occupational and environmental health · 2018Article
- Ambient Air Pollution and Cancer Mortality in the Cancer Prevention Study II.Environmental health perspectives · 2017Article
- Association between inflammation processes, DNA damage, and exposure to environmental pollutants.Environmental science and pollution research international · 2017Article
- Impact of prenatal exposure to polycyclic aromatic hydrocarbons from maternal diet on birth outcomes: a birth cohort study in Korea.Public health nutrition · 2016Article
- Petroleum coke in the urban environment: a review of potential health effects.International journal of environmental research and public health · 2015Review
- Urinary 1-hydroxypyrene is associated with oxidative stress and inflammatory biomarkers in acute Myocardial Infarction.International journal of environmental research and public health · 2014Article
- Investigation of maternal environmental exposures in association with self-reported preterm birth.Reproductive toxicology (Elmsford, N.Y.) · 2014Article
- Polycyclic aromatic hydrocarbon biomarkers and serum markers of inflammation. A positive association that is more evident in men.Environmental research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the usefulness and specificity of urinary 1-hydroxypyrene (1-OHPu) as a biomarker of the exposure from urban pollution to polycyclic aromatic hydrocarbons (PAHs) among outdoor workers in a meta-analysis. Our meta-analysis was performed according to standard methods, and the results show that the concentrations of 1-OHPu tend to be higher in exposed workers than in unexposed workers (if we exclude two highly heterogeneous articles), in exposed non-smokers than in unexposed non-smokers and in exposed than in unexposed workers who were carriers of the CYP1A1 genotype and in those with the glutathione-S-transferase M1 (-)genotype. These genotypes enhance the effect of exposure, particularly in non-smokers. Smoking reduces the differences between exposed and unexposed subjects. In conclusion, our results suggest that the use of the 1-OHPu biomarker appears to be reliable for studying occupational exposure to PAHs from urban pollution, as long as environmental and behavioural factors are considered.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.