ArticleBMJ open2013
Are children carrying the burden of broad-spectrum antibiotics in general practice? Prescription pattern for paediatric outpatients with respiratory tract infections in Norway.
Article in BMJ open, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00272155 (Can Antibiotic Prescriptions in Respiratory Tract Infections be Improved? A Cluster Randomized Educational Intervention in General Practice), which is not on this map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Can Antibiotic Prescriptions in Respiratory Tract Infections be Improved? A Cluster Randomized Educational Intervention in General Practice
Who cites it
20 citing papers in PubMed.
- Trial
- Paediatric outpatient antibiotic utilization patterns and use of healthcare services before, during and after the COVID-19 pandemic: interrupted time series analysis using data from Norway and Japan.The Journal of antimicrobial chemotherapy · 2026Article
- Antibiotic Usage for Treatment of Acute Upper Respiratory Tract Infections in Children in Lithuania from 2018 to 2022.Antibiotics (Basel, Switzerland) · 2025Article
- The impact of drug palatability on prescribing and dispensing of antibiotic formulations for paediatric patients: a cross-sectional survey of general practitioners and pharmacists.Family practice · 2024Article
- Trends and Patterns of Antibiotic Prescriptions in Primary Care Institutions in Southwest China, 2017-2022.Infection and drug resistance · 2023Article
- Throat infections and use of streptococcal antigen test and antibiotic treatment in general practice; a web-based survey.Scandinavian journal of primary health care · 2022Article
- Lifetime antimicrobial use is associated with weight status in early adolescence-A register-based cohort study.Pediatric obesity · 2021Article
- Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes.Nature communications · 2020Article
- Relationship between Maternal and First Year of Life Dispensations of Antibiotics and Antiasthmatics.Antibiotics (Basel, Switzerland) · 2018Article
- Prescribing antibiotics when the stakes are higher - do GPs prescribe less when patients are pregnant? A retrospective observational study.BJGP open · 2018Article
- Treatment of Community-Acquired Pneumonia: Are All Countries Treating Children in the Same Way? A Literature Review.International journal of pediatrics · 2017Review
- Antibiotic prescribing for upper respiratory infections among children in rural China: a cross-sectional study of outpatient prescriptions.Global health action · 2017Article
- Out-of-hours antibiotic prescription after screening with C reactive protein: a randomised controlled study.BMJ open · 2016Observational
- Clinical predictors of antibiotic prescribing for acutely ill children in primary care: an observational study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2015Observational
- Trends in paediatric macrolide use in five European countries-a population-based study.European journal of clinical pharmacology · 2015Article
- Workload and management of childhood fever at general practice out-of-hours care: an observational cohort study.BMJ open · 2015Observational
- Drug prescribing pattern for under-fives in a paediatric clinic in South-Western Nigeria.Ethiopian journal of health sciences · 2015Article
- Antibiotic Usage Prior and During Hospitalization for Clinical Severe Pneumonia in Children under Five Years of Age in Rabat, Morocco.Antibiotics (Basel, Switzerland) · 2013Article
- Drug Utilisation Patterns in Children Admitted to a Paediatric General Medical Ward in Five Countries.Drugs - real world outcomesArticle
- Antibiotic Prescription Trends Among Pediatric Patients in Dessie Comprehensive Specialized Hospital, Ethiopia.Sage open pediatricsArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the antibiotic prescription pattern and factors that influence the physicians' choice of antibiotic.
designObservational study.
settingPrimary healthcare in Norway, December 2004 through November 2005.
participants426 general practitioners, GPs, in Norway, giving 24 888 respiratory tract infection episodes with 19 938 children aged 0-6 years. OUTCOME MEASURES: Assess antibiotic prescription details and patient and GP characteristics associated with broad-spectrum and narrow-spectrum antibiotic use.
resultsOf the 24 888 episodes in the study, 26.2% (95% CI 25.7% to 26.8%) included an antibiotic prescription. Penicillin V accounted for 42% and macrolide antibiotics for 30%. The prescription rate varied among the physicians, with a mean of 25.5% (95% CI 24.2% to 26.7%). Acute tonsillitis gave the highest odds for a prescription, OR 33.6 (95% CI 25.7% to 43.9%), compared to 'acute respiratory tract infections and symptoms' as a reference group. GPs with a prescription rate of 33.3% or higher had the larger probability for broad-spectrum antibiotic prescriptions, OR 3.33 (95% CI 2.01% to 5.54%). Antibiotic prescriptions increased with increasing patient age.
conclusionsWe found a low antibiotic prescription rate for childhood respiratory tract infections. However, our figures indicate an overuse of macrolide antibiotics and penicillins with extended spectrum, more so than in the corresponding study including the adult population. Palatability of antibiotic suspensions and other administrative challenges affect medication compliance in children. To help combat antibiotic resistance, guidelines need to be followed, in particular for our youngest patients. TRIAL REGISTRATION NUMBER (CLINICALTRIALS.ORG): NCT00272155.
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