ReviewTrends in endocrinology and metabolism: TEM2013
Aging signaling pathways and circadian clock-dependent metabolic derangements.
Review in Trends in endocrinology and metabolism: TEM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Chrononutrition, Body Composition, and Resting Metabolic Rate Among College Students: A Cross-Sectional Study.Nutrients · 2026Article
- Multifaceted dynamics of circadian timing system influence aging and longevity.Biogerontology · 2025Review
- The intricate link between circadian rhythms and aging: can resetting our circadian clock hold the key to longevity?Biogerontology · 2025Review
- Article
- Unraveling the interplay between sleep, redox metabolism, and aging: implications for brain health and longevity.Frontiers in aging · 2025Review
- Article
- Inhibition of Expression of the Circadian Clock GeneInternational journal of molecular sciences · 2023Article
- Sleep Modulates Alcohol Toxicity inInternational journal of molecular sciences · 2022Article
- Chronotype Profile, Stress, Depression Level, and Temporomandibular Symptoms in Students with Type D Personality.Journal of clinical medicine · 2022Article
- The Association Between Dry Eye and Sleep Disorders: The Evidence and Possible Mechanisms.Nature and science of sleep · 2022Review
- Effects of Shift Work in a Sample of Italian Nurses: Analysis of Rest-Activity Circadian Rhythm.International journal of environmental research and public health · 2021Article
- Biological Rhythm and Chronotype: New Perspectives in Health.Biomolecules · 2021Review
- Altered expression of clock and clock-controlled genes in a hSOD1-linked amyotrophic lateral sclerosis mouse model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- The GH-IGF-1 Axis in Circadian Rhythm.Frontiers in molecular neuroscience · 2021Review
- BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy.Protein & cell · 2020Article
- Aging and the clock: Perspective from flies to humans.The European journal of neuroscience · 2020Review
- The Effects of Meal Timing and Frequency, Caloric Restriction, and Fasting on Cardiovascular Health: an Overview.Journal of lipid and atherosclerosis · 2020Review
- The Mechanism of Programmed Aging: The Way to Create a Real Remedy for Senescence.Current aging science · 2020Review
- Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge.Nature communications · 2019Article
- Maternal eating behavior is a major synchronizer of fetal and postnatal peripheral clocks in mice.Cellular and molecular life sciences : CMLS · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The circadian clock machinery orchestrates organism metabolism to ensure that development, survival, and reproduction are attuned to diurnal environmental variations. For unknown reasons, there is a decline in circadian rhythms with age, concomitant with declines in the overall metabolic tissue homeostasis and changes in the feeding behavior of aged organisms. This disruption of the relationship between the clock and the nutrient-sensing networks might underlie age-related diseases; overall, greater knowledge of the molecular mediators of and variations in clock networks during lifespan may shed light on the aging process and how it may be delayed. In this review we address the complex links between the circadian clock, metabolic (dys)functions, and aging in different model organisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.