ArticleReproductive sciences (Thousand Oaks, Calif.)2013
Regional differences in rat vaginal smooth muscle contractility and morphology.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Functional outcome of the anterior vaginal wall in a pelvic surgery injury rat model after treatment with stem cell-derived progenitors of smooth muscle cells.Stem cell research & therapy · 2024Article
- Functional outcome of the anterior vaginal wall in a pelvic surgery injury rat model after treatment with stem cell-derived progenitors of smooth muscle cells.Research square · 2024Article
- Long-term effects of vaginal surgery and endogenous ovarian hormones on the vagina and bladder.Sexual medicine · 2023Article
- Smooth muscle contribution to vaginal viscoelastic response.Journal of the mechanical behavior of biomedical materials · 2023Article
- Advances in vaginal bioengineering: Applications, techniques, and needs.Current research in physiology · 2023Review
- Smooth Muscle Organization and Nerves in the Rat Vagina: A First Look Using Tissue Clearing and Immunolabeling.Annals of biomedical engineering · 2022Article
- Role of fibulin-5 insufficiency and prolapse progression on murine vaginal biomechanical function.Scientific reports · 2021Article
- Tear propagation in vaginal tissue under inflation.Acta biomaterialia · 2021Article
- Contractile Properties of Vaginal Tissue.Journal of biomechanical engineering · 2020Review
- Pelvic Organ Prolapse: A Review of In Vitro Testing of Pelvic Support Mechanisms.Ochsner journal · 2020Review
- New Zealand white rabbit: a novel model for prolapse mesh implantation via a lumbar colpopexy.International urogynecology journal · 2020Article
- Impact of polypropylene prolapse mesh on vaginal smooth muscle in rhesus macaque.American journal of obstetrics and gynecology · 2019Article
- Smooth muscle regional contribution to vaginal wall function.Interface focus · 2019Article
- Biaxial Mechanical Assessment of the Murine Vaginal Wall Using Extension-Inflation Testing.Journal of biomechanical engineering · 2017Article
- Nerve-induced responses of mouse vaginal smooth muscle.Pflugers Archiv : European journal of physiology · 2017Article
- The impact of prolapse mesh on vaginal smooth muscle structure and function.BJOG : an international journal of obstetrics and gynaecology · 2016Article
- Regional variation in tissue composition and biomechanical properties of postmenopausal ovine and human vagina.PloS one · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The objective of this study was to define the regional differences in rat vaginal smooth muscle contractility and morphology. We evaluated circumferential segments from the proximal, middle, and distal rat vagina (n = 21) in vitro. Contractile responses to carbachol, phenylephrine, potassium chloride, and electrical field stimulation (EFS) were measured. Immunohistochemical analyses were also performed. The dose-response curves for carbachol- and phenylephrine-dependent contractions were different in the distal (P = .05, P = .04) compared to the proximal/middle regions. Adjusted for region-dependent changes in contractility, the distal vagina generated lower force in response to carbachol and higher force in response to phenylephrine. There was less force with increasing EFS frequency in the distal (P = .03), compared to the proximal/middle regions. Cholinergic versus adrenergic nerves were more frequent in the proximal region (P = .03). In summary, the results indicate that functional and morphological differences in smooth muscle and nerve fibers of the distal versus proximal/middle regions of the vagina exist.
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Registered trials
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