ArticleMedical gas research2013
Normobaric hyperoxia-based neuroprotective therapies in ischemic stroke.
Article in Medical gas research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Enhancing Blood-Brain Barrier Integrity in Patients With Acute Ischemic Stroke Via Normobaric Hyperoxia.Journal of the American Heart Association · 2024Trial
- The intersection of circadian rhythms and the blood-brain barrier with drug efficacy and delivery in neurological disorders.Advanced drug delivery reviews · 2025Review
- Pyruvate Dehydrogenase Complex in Neonatal Hypoxic-Ischemic Brain Injury.ACS pharmacology & translational science · 2024Review
- Exploiting moderate hypoxia to benefit patients with brain disease: Molecular mechanisms and translational research in progress.Neuroprotection (Chichester, England) · 2023Article
- Normobaric hyperoxia plays a neuroprotective role after cerebral ischemia by maintaining the redox homeostasis and the level of connexin43 in astrocytes.CNS neuroscience & therapeutics · 2022Article
- How can imaging in acute ischemic stroke help us to understand tissue fate in the era of endovascular treatment and cerebroprotection?Neuroradiology · 2022Article
- Normobaric oxygen therapy attenuates hyperglycolysis in ischemic stroke.Neural regeneration research · 2021Article
- The Association Between Arterial Oxygen Level and Outcome in Neurocritically Ill Patients is not Affected by Blood Pressure.Neurocritical care · 2021Article
- Normobaric Oxygen (NBO) Therapy Reduces Cerebral Ischemia/Reperfusion Injury through Inhibition of Early Autophagy.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Prehospital supplemental oxygen for acute stroke - A retrospective analysis.The American journal of emergency medicine · 2020Article
- Cocktail treatment, a promising strategy to treat acute cerebral ischemic stroke?Medical gas research · 2016Review
- Hyperoxia in intensive care, emergency, and peri-operative medicine: Dr. Jekyll or Mr. Hyde? A 2015 update.Annals of intensive care · 2015Article
- Article
- Does normobaric hyperoxia increase oxidative stress in acute ischemic stroke? A critical review of the literature.Medical gas research · 2015Article
- Supplemental oxygen delivery to suspected stroke patients in pre hospital and emergency department settings.Medical gas research · 2014Article
- Extended normobaric hyperoxia therapy yields greater neuroprotection for focal transient ischemia-reperfusion in rats.Medical gas research · 2014Article
- Review
- Article
- Oxygen or cooling, to make a decision after acute ischemia stroke.Medical gas researchReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke is a leading cause of death and disability due to disturbance of blood supply to the brain. As brain is highly sensitive to hypoxia, insufficient oxygen supply is a critical event contributing to ischemic brain injury. Normobaric hyperoxia (NBO) that aims to enhance oxygen delivery to hypoxic tissues has long been considered as a logical neuroprotective therapy for ischemic stroke. To date, many possible mechanisms have been reported to elucidate NBO's neuroprotection, such as improving tissue oxygenation, increasing cerebral blood flow, reducing oxidative stress and protecting the blood brain barrier. As ischemic stroke triggers a battery of damaging events, combining NBO with other agents or treatments that target multiple mechanisms of injury may achieve better outcome than individual treatment alone. More importantly, time loss is brain loss in acute cerebral ischemia. NBO can be a rapid therapy to attenuate or slow down the evolution of ischemic tissues towards necrosis and therefore "buy time" for reperfusion therapies. This article summarizes the current literatures on NBO as a simple, widely accessible, and potentially cost-effective therapeutic strategy for treatment of acute ischemic stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.