Evidence map›Paper›PMID 23298659›Full record

ReviewCurrent opinion in genetics & development2013

The role of chromatin insulators in nuclear architecture and genome function.

Kevin Van Bortle, Victor G Corces

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Article
  2. Article
  3. Viral remodeling of the 4D nucleome.Experimental & molecular medicine · 2024
    Review
  4. Article
  5. Article
  6. Review
  7. Signaling by Steroid Hormones in the 3D Nuclear Space.International journal of molecular sciences · 2018
    Review
  8. Vitamin D Genomics: FromFrontiers in endocrinology · 2018
    Review
  9. Article
  10. The β-NADOncotarget · 2017
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kevin Van BortleDepartment of Biology, Emory University, Atlanta, GA 30322, United States.
Victor G Corces

Funding

MOLECULAR BASIS OF SUPPRESSION IN DROSOPHILAR01GM035463 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI CORCES, VICTOR G. · 1986 to 2020
$10.7M
NIGMS NIH HHS R01 GM035463NIGMS NIH HHS R01GM035463
6 · The paper itself

Abstract

Eukaryotic genomes are intricately arranged into highly organized yet dynamic structures that underlie patterns of gene expression and cellular identity. The recent adaptation of novel genomic strategies for assaying nuclear architecture has significantly extended and accelerated our ability to query the nature of genome organization and the players involved. In particular, recent explorations of physical arrangements and chromatin landscapes in higher eukaryotes have demonstrated that chromatin insulators, which mediate functional interactions between regulatory elements, appear to play an important role in these processes. Here we reflect on current findings and our rapidly expanding understanding of insulators and their role in nuclear architecture and genome function.

Indexed as

EukaryotaAnimalsCCCTC-Binding FactorCell CycleCell DifferentiationCell NucleusChromatinChromosomesGene Expression RegulationGenomeHumansInsulator ElementsRepressor ProteinsCCCTC-Binding FactorChromatinCTCF protein, humanRepressor Proteins

Identifiers

PMID23298659
PMCPMC3632654

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.