Evidence map›Paper›PMID 23298648›Full record

ArticleTwin research and human genetics : the official journal of the International Society for Twin Studies2013

The Adult Netherlands Twin Register: twenty-five years of survey and biological data collection.

Gonneke Willemsen, Jacqueline M Vink, Abdel Abdellaoui, Anouk den Braber, Jenny H D A van Beek, Harmen H M Draisma, Jenny van Dongen, Dennis van 't Ent, Lot M Geels, Rene van Lien and 12 more

Abstract readTwin Study
In one paragraph

Article in Twin research and human genetics : the official journal of the International Society for Twin Studies, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  16. Genetic, vascular and amyloid components of cerebral blood flow in a preclinical population.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Gonneke WillemsenDepartment of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands. a.h.m.willemsen@vu.nl
Jacqueline M Vink
Abdel Abdellaoui
Anouk den Braber
Jenny H D A van Beek
Harmen H M Draisma
Jenny van Dongen
Dennis van 't Ent
Lot M Geels
Rene van Lien
Lannie Ligthart
Mathijs Kattenberg
Hamdi Mbarek
Marleen H M de Moor
Melanie Neijts
Rene Pool
Natascha Stroo
Cornelis Kluft
H Eka D Suchiman
P Eline Slagboom
Eco J C de Geus
Dorret I Boomsma

Funding

Integration of Genomics & Transcriptomics in Normal Twins & Major DepressionRC2MH089951 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2009 to 2010
$6.5M
Psychometric and Genetic Assessments of Substance UseR37DA018673 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI NEALE, MICHAEL CHURTON · 2005 to 2014
$3.7M
DETECTING SUSCEPTIBILITY LOCI FOR RECURRENT DEPRESSIONR01MH059160 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI SULLIVAN, PATRICK F · 2000 to 2002
$2.7M
Psychometric and Genetic Assessments of Substance UseR01DA018673 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI NEALE, MICHAEL CHURTON · 2004 to 2019
$2.3M
The role of genes and environment in anxiety spectrum disordersR01MH087646 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI HETTEMA, JOHN M · 2010 to 2013
$1.9M
European Research Council 230374European Research Council 284167NIDA NIH HHS 4R37DA018673-06NIDA NIH HHS 5R37DA018673-03NIDA NIH HHS R01 DA018673NIDA NIH HHS R37 DA018673NIMH NIH HHS 1R01 MH087646-01A1NIMH NIH HHS 1RC2 MH089951-01NIMH NIH HHS R01 MH059160NIMH NIH HHS R01 MH087646NIMH NIH HHS RC2 MH089951NIMH NIH HHS RFA MH08120
6 · The paper itself

Abstract

Over the past 25 years, the Adult Netherlands Twin Register (ANTR) has collected a wealth of information on physical and mental health, lifestyle, and personality in adolescents and adults. This article provides an overview of the sources of information available, the main research findings, and an outlook for the future. Between 1991 and 2012, longitudinal surveys were completed by twins, their parents, siblings, spouses, and offspring. Data are available for 33,957 participants, with most individuals having completed two or more surveys. Smaller projects provided in-depth phenotyping, including measurements of the autonomic nervous system, neurocognitive function, and brain imaging. For 46% of the ANTR participants, DNA samples are available and whole genome scans have been obtained in more than 11,000 individuals. These data have resulted in numerous studies on heritability, gene x environment interactions, and causality, as well as gene finding studies. In the future, these studies will continue with collection of additional phenotypes, such as metabolomic and telomere length data, and detailed genetic information provided by DNA and RNA sequencing. Record linkage to national registers will allow the study of morbidity and mortality, thus providing insight into the development of health, lifestyle, and behavior across the lifespan.

Indexed as

Biological Specimen BanksBiomedical ResearchGene-Environment InteractionRegistriesAdolescentAdultDiseases in TwinsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLongitudinal StudiesMaleNetherlandsTwinsYoung Adult

Identifiers

PMID23298648
PMCPMC3739974

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.