SynthesisGenomics2013
Pathway-based genetic analysis of preterm birth.
Synthesis in Genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration.Nature communications · 2019Pooled it
- Targeted Sequencing and Meta-Analysis of Preterm Birth.PloS one · 2016Pooled it
- Stress During Pregnancy and Epigenetic Modifications to Offspring DNA: A Systematic Review of Associations and Implications for Preterm Birth.The Journal of perinatal & neonatal nursingPooled it
- Trial
- Real-time monitoring of metabolic plasticity in Mycoplasma gallisepticum under varying nutrient conditions via DART-HRMS.Scientific reports · 2026Article
- Metabolic signature ofFrontiers in veterinary science · 2023Article
- A genome-wide and candidate gene association study of preterm birth in Korean pregnant women.PloS one · 2023Article
- Transcriptome analysis and cytochrome P450 monooxygenase reveal the molecular mechanism of Bisphenol A degradation by Pseudomonas putida strain YC-AE1.BMC microbiology · 2022Article
- Protein interaction networks define the genetic architecture of preterm birth.Scientific reports · 2022Article
- Activated Neutrophils Propagate Fetal Membrane Inflammation and Weakening through ERK and Neutrophil Extracellular Trap-Induced TLR-9 Signaling.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Gaining a deeper understanding of social determinants of preterm birth by integrating multi-omics data.Pediatric research · 2021Review
- The significance of the placental genome and methylome in fetal and maternal health.Human genetics · 2020Review
- Epigenetic biomarkers and preterm birth.Environmental epigenetics · 2020Review
- Effect of prematurity on genome wide methylation in the placenta.BMC medical genetics · 2019Article
- Risk of spontaneous preterm birth and fetal growth associates with fetal SLIT2.PLoS genetics · 2019Article
- Genomic and molecular characterization of preterm birth.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Spontaneous premature birth as a target of genomic research.Pediatric research · 2019Review
- Machine learning approach to literature mining for the genetics of complex diseases.Database : the journal of biological databases and curation · 2019Article
- Screening for spontaneous preterm birth and resultant therapies to reduce neonatal morbidity and mortality: A review.Seminars in fetal & neonatal medicine · 2018Review
- Spontaneous preterm birth: advances toward the discovery of genetic predisposition.American journal of obstetrics and gynecology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Preterm birth in the United States is now 12%. Multiple genes, gene networks, and variants have been associated with this disease. Using a custom database for preterm birth (dbPTB) with a refined set of genes extensively curated from literature and biological databases, we analyzed GWAS of preterm birth for complete genotype data on nearly 2000 preterm and term mothers. We used both the curated genes and a genome-wide approach to carry out a pathway-based analysis. There were 19 significant pathways, which withstood FDR correction for multiple testing that were identified using both the curated genes and the genome-wide approach. The analysis based on the curated genes was more significant than genome-wide in 15 out of 19 pathways. This approach demonstrates the use of a validated set of genes, in the analysis of otherwise unsuccessful GWAS data, to identify gene-gene interactions in a way that enhances statistical power and discovery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.