SynthesisArthritis research & therapy2013
Role of ultrasonography in diagnosing early rheumatoid arthritis and remission of rheumatoid arthritis--a systematic review of the literature.
Synthesis in Arthritis research & therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- The role of ultrasound in diagnosing rheumatoid arthritis, what do we know? An updated review.Rheumatology international · 2017Pooled it
- Clinical, Ultrasound, and Predictability Outcomes Following Certolizumab Pegol Treatment (with Methotrexate) in Patients with Moderate-to-Severe Rheumatoid Arthritis: 52-Week Results from the CZP-SPEED Study.Advances in therapy · 2018Trial
- Clinical and ultrasound remission at 48 weeks of upadacitinib in rheumatoid arthritis: real-world results from the Italian multicenter UPARAREMUS study.Arthritis research & therapy · 2025Observational
- Clinical and Ultrasonographic Remission in Bio-naïve and Bio-failure Patients with Rheumatoid Arthritis at 24 Weeks of Upadacitinib Treatment: The UPARAREMUS Real-Life Study.Rheumatology and therapy · 2024Article
- Development of a guideline for the use of ultrasonography in rheumatoid arthritis: Preliminary recommendations.La Tunisie medicale · 2023Article
- Factors associated with subclinical inflammation of wrist joints in rheumatoid arthritis patients with low or no disease activity- a RA ultrasound registry study.BMC musculoskeletal disorders · 2023Article
- High-frequency ultrasound in patients with seronegative rheumatoid arthritis.Scientific reports · 2022Article
- A Review of Clinical Applications for Super-resolution Ultrasound Localization Microscopy.Current medical science · 2022Review
- When and how should we use imaging in individuals at risk of rheumatoid arthritis?Frontiers in medicine · 2022Review
- Ultrasound as a Biomarker in Rheumatic Diseases.Diagnostics (Basel, Switzerland) · 2020Review
- Should ultrasound be used routinely in the diagnosis of rheumatoid arthritis?Irish journal of medical science · 2020Review
- The changing role of ultrasonography examination in patients with rheumatoid arthritis in light of recent studies.Reumatologia · 2020Review
- Ultrasound and multi-biomarker disease activity score for assessing and predicting clinical response to tofacitinib treatment in patients with rheumatoid arthritis.BMC rheumatology · 2020Article
- The folate receptor β as a macrophage-mediated imaging and therapeutic target in rheumatoid arthritis.Drug delivery and translational research · 2019Review
- The impact of rheumatologist-performed ultrasound on diagnosis and management of inflammatory arthritis in routine clinical practice.BMC musculoskeletal disorders · 2017Observational
- The relationship between synovitis quantified by an ultrasound 7-joint inflammation score and physical disability in rheumatoid arthritis - a cohort study.Arthritis research & therapy · 2017Article
- Pixel-based approach to assess contrast-enhanced ultrasound kinetics parameters for differential diagnosis of rheumatoid arthritis.Journal of medical imaging (Bellingham, Wash.) · 2015Article
- The Role of Power Doppler Ultrasonography as Disease Activity Marker in Rheumatoid Arthritis.Disease markers · 2015Review
- Presence of power Doppler synovitis in rheumatoid arthritis patients with synthetic and/or biological disease-modifying anti-rheumatic drug-induced clinical remission: experience from a Chinese cohort.Clinical rheumatology · 2014Article
- Ultrasonographic assessment reveals detailed distribution of synovial inflammation in Blau syndrome.Arthritis research & therapy · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionUltrasonography (US) might have an added value to clinical examination in diagnosing early rheumatoid arthritis (RA) and assessing remission of RA. We aimed to clarify the added value of US in RA in these situations performing a systematic review.
methodsA systematic literature search was performed for RA, US, diagnosis and remission. Methodological quality was assessed; the wide variability in the design of studies prohibited pooling of results.
resultsSix papers on the added value of US diagnosing early RA were found, in which at least bilateral metacarpophalangeal (MCP), wrists and metatarsophalangeal (MTP) joints were scanned. Compared to clinical examination, US was superior with regard to detecting synovitis and predicting progression to persistent arthritis or RA. Eleven papers on assessing remission were identified, in which at least the wrist and the MCP joints of the dominant hand were scanned. Often US detected inflammation in patients clinically in remission, irrespective of the remission criteria used. Power Doppler signs of synovitis predicted X-ray progression and future flare in patients clinically in remission.
conclusionsUS appears to have added value to clinical examination for diagnosing of RA when scanning at least MCP, wrist and MTP joints, and, when evaluating remission of RA, scanning at least wrist and MCP joints of the dominant hand. For both purposes primarily power Doppler US might be used since its results are less equivocal than those of greyscale US.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.