ArticleDiagnostic pathology2013
Correlation of microRNA-372 upregulation with poor prognosis in human glioma.
Article in Diagnostic pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Prognostic role of microRNA-21 expression in gliomas: a meta-analysis.Journal of neuro-oncology · 2016Pooled it
- Research trends in microRNAs in glioma tumors: A data-driven exploration using a bibliometric approach.IBRO neuroscience reports · 2026Review
- Feedback Modulation between Human INO80 Chromatin Remodeling Complex and miR-372 in HCT116 Cells.International journal of molecular sciences · 2023Article
- Zinc Finger E-Box Binding Homeobox Family: Non-Coding RNA and Epigenetic Regulation in Gliomas.Biomedicines · 2023Review
- Deep learning-based breast cancer grading and survival analysis on whole-slide histopathology images.Scientific reports · 2022Article
- MiR-372-3p Functions as a Tumor Suppressor in Colon Cancer by Targeting MAP3K2.Frontiers in genetics · 2022Article
- MiRNA155HG polymorphisms influenced the risk of liver cancer among the Han Chinese population.BMC medical genetics · 2020Article
- Plasma-based microRNA signatures in early diagnosis of breast cancer.Molecular genetics & genomic medicine · 2020Article
- MicroRNA-371-3 cluster as biomarkers for the diagnosis and prognosis of cancers.Cancer management and research · 2019Article
- Efficacy and prognosis of surgery combined withOncology letters · 2017Article
- MicroRNAs as prognostic biomarker and relapse indicator in leukemia.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2017Review
- Downregulation of miR-154 in human glioma and its clinicopathological and prognostic significance.The Journal of international medical research · 2016Article
- miR-372 suppresses tumour proliferation and invasion by targeting IGF2BP1 in renal cell carcinoma.Cell proliferation · 2015Article
- Decreased Expression of miR-15b in Human Gliomas is Associated with Poor Prognosis.Cancer biotherapy & radiopharmaceuticals · 2015Article
- miR-372 inhibits p62 in head and neck squamous cell carcinoma in vitro and in vivo.Oncotarget · 2015Article
- MicroRNA expression signatures determine prognosis and survival in glioblastoma multiforme--a systematic overview.Molecular neurobiology · 2014Review
- Quantification of myocardial fibrosis by digital image analysis and interactive stereology.Diagnostic pathology · 2014Article
- Prognostic value of miR-96 in patients with acute myeloid leukemia.Diagnostic pathology · 2014Article
- Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128.Molecular cancer · 2014Review
- MicroRNA-21 expression is associated with overall survival in patients with glioma.Diagnostic pathology · 2013Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNA-372 (miR-372) acts as either an oncogenic miRNA or an anti-oncomiR in various human malignancies. However, its roles in gliomas have not been elucidated. To address this problem, we here detected miR-372 expression in human gliomas and non-neoplastic brain tissues by real-time quantitative RT-PCR assay. The association of miR-372 expression with clinicopathological factors or prognosis of glioma patients was also statistically analyzed. As the results, miR-372 expression levels were significantly upregulated in glioma tissues compared to the corresponding non-neoplastic brain tissues (P<0.001). In addition, the high miR-372 expression was significantly associated with the advanced pathological grade (P=0.008) and the low Karnofsky performance score (KPS) of glioma patients (P=0.01). Moreover, the overall survival of patients with high miR-372 expression was dramatically shorter than those with low miR-372 expression (P<0.001). Furthermore, multivariate Cox regression analysis indicated that miR-372 expression was an independent prognostic factor for glioma patients (P=0.008). More importantly, subgroup analyses according to tumor pathological grade revealed that the cumulative overall survival of glioma patients with advanced pathological grades was significantly worse for high miR-372 expression group than for low miR-372 expression group (P<0.001), but no significant difference was found for patients with low pathological grades (P=0.08). Taken together, these data offer the convincing evidence for the first time that miR-372 may act as an oncogenic miRNA in gliomas and represent a potential regulator of aggressive development and a candidate prognostic marker for this malignancy, especially for advanced tumors with high pathological grades. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1707761328850011.
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