ArticleThe Journal of chemical physics2013
The effect of divalent vs. monovalent ions on the swelling of mucin-like polyelectrolyte gels: governing equations and equilibrium analysis.
Article in The Journal of chemical physics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Ion-mediated effects of glycosylation on the disordered mucin domain: Insights from coarse-grained simulations.Biophysical journal · 2025Article
- A Model of Gastric Mucosal pH Regulation: Extending Sensitivity Analysis Using Sobol' Indices to Understand Higher Moments.Bulletin of mathematical biology · 2024Article
- Development and Characterization of COACS omega · 2023Article
- Deswelling Dynamics of Chemically-Active Polyelectrolyte Gels.Computational Science--ICCS ... : international conference ... : proceedings. ICCS · 2023Article
- A Computational Framework for the Swelling Dynamics of Mucin-like Polyelectrolyte Gels.Journal of non-Newtonian fluid mechanics · 2023Article
- A mathematical model for cell-induced gel contraction incorporating osmotic effects.Journal of mathematical biology · 2022Article
- Dynamic model of monovalent-divalent cation exchange in polyelectrolyte gels.Physical review materials · 2022Article
- Modeling and Simulation of the Ion-Binding-Mediated Swelling Dynamics of Mucin-like Polyelectrolyte Gels.Gels (Basel, Switzerland) · 2021Article
- Principles of slowed hydrogen diffusion through a mucus layer.Physical review. E · 2021Article
- Physiological insights into electrodiffusive maintenance of gastric mucus through sensitivity analysis and simulations.Journal of mathematical biology · 2021Article
- Ion-Induced Volume Transition in Gels and Its Role in Biology.Gels (Basel, Switzerland) · 2021Review
- ENHANCED ELECTRODIFFUSIVE TRANSPORT ACROSS A MUCUS LAYER.SIAM journal on applied mathematics · 2021Article
- Article
- Electrodiffusion-Mediated Swelling of a Two-Phase Gel Model of Gastric Mucus.Gels (Basel, Switzerland) · 2018Article
- Engineering the Mucus Barrier.Annual review of biomedical engineering · 2018Review
- A physics-based model for maintenance of the pH gradient in the gastric mucus layer.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- Effect of calcium/sodium ion exchange on the osmotic properties and structure of polyelectrolyte gels.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We introduce a comprehensive model of a mucin-like polyelectrolyte gel swelling-deswelling which includes the ion-mediated crosslinking of polymer strands and the exchange of divalent and monovalent ions in the gel. The gel is modeled as a multi-phase mixture which accounts for the polymer and solvent volume fractions and velocities as well as ionic species concentrations. Motion is determined by force balances involving viscous, drag, and chemical forces. The chemical forces are derived from a free energy which includes entropic contributions as well as the chemical and electrostatic interactions among the crosslinked polymer, uncrosslinked polymer, and the ionic solvent. The unified derivation produces all the classical effects (van't Hoff osmotic pressure, Donnan equilibrium potential, Nernst-Planck motion of ions) as well as expressions for Flory interaction parameter and the standard free energy parameters that explicitly depend on the gel chemistry and crosslink structure. For this model, we show how the interplay between ionic bath concentrations, ionic binding, and transient divalent crosslinking leads to a variety of swelled and deswelled phases/phase transitions. In particular, we show how the absorption of divalent ions can lead to a massive deswelling of the gel. We conclude that the unique properties of mucin-like gels can be explained by their ionic binding affinities and transient divalent crosslinking.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.