ArticleInfection and immunity2013
Implication of glycerol and phospholipid transporters in Mycoplasma pneumoniae growth and virulence.
Article in Infection and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 59 citations in OpenAlex.
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- Identification and characterization of ugpE associated with the full virulence of Streptococcus suis.Veterinary research · 2025Article
- Advances in adhesion-related pathogenesis inFrontiers in microbiology · 2025Review
- Novel Nuclease MbovP701 with a Yqaj Domain Is Interrelated with the Growth ofMicroorganisms · 2024Article
- Genes required for survival and proliferation ofApplied and environmental microbiology · 2024Article
- Metabolomics-based study of the effect of dietary N-carbamoylglutamic acid addition to heifers in late pregnancy on newborn calves.Frontiers in veterinary science · 2024Article
- Characterization of Virulence-Associated Traits in Mycoplasma penetrans Strains Acting as Likely Etiological Agents of Idiopathic Nongonococcal Urethritis.The Journal of infectious diseases · 2023Article
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- Kukoamine A ImprovesBioMed research international · 2022Article
- Genome-resolved metagenomics suggests a mutualistic relationship between Mycoplasma and salmonid hosts.Communications biology · 2021Article
- AApplied and environmental microbiology · 2021Article
- Review
- Evaluating the Genetic Capacity ofFrontiers in microbiology · 2021Article
- MtcB, a member of the MttB superfamily from the human gut acetogenThe Journal of biological chemistry · 2020Article
- Transcriptional response to metal starvation in the emerging pathogenEmerging microbes & infections · 2020Article
- Pathogenic Analysis of the Bronchoalveolar Lavage Fluid Samples With Pediatric RefractoryFrontiers in cellular and infection microbiology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycoplasma pneumoniae, the causative agent of atypical pneumonia, is one of the bacteria with the smallest genomes that are nonetheless capable of independent life. Because of their longstanding close association with their human host, the bacteria have undergone reductive evolution and lost most biosynthetic abilities. Therefore, they depend on nutrients provided by the host that have to be taken up by the cell. Indeed, M. pneumoniae has a large set of hitherto unexplored transporters and lipoproteins that may be implicated in transport processes. Together, these proteins account for about 17% of the protein complement of M. pneumoniae. In the natural habitat of M. pneumoniae, human lung epithelial surfaces, phospholipids are the major available carbon source. Thus, the uptake and utilization of glycerol and glycerophosphodiesters that are generated by the activity of lipases are important for the nutrition of M. pneumoniae in its common habitat. In this study, we have investigated the roles of several potential transport proteins and lipoproteins in the utilization of glycerol and glycerophosphodiesters. On the basis of experiments with the corresponding mutant strains, our results demonstrate that the newly identified GlpU transport protein (MPN421) is responsible for the uptake of the glycerophosphodiester glycerophosphocholine, which is then intracellularly cleaved to glycerol-3-phosphate and choline. In addition, the proteins MPN076 and MPN077 are accessory factors in glycerophosphocholine uptake. Moreover, the lipoproteins MPN133 and MPN284 are essential for the uptake of glycerol. Our data suggest that they may act as binding proteins for glycerol and deliver glycerol molecules to the glycerol facilitator GlpF.
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