ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2013
Unusual properties of the cytochrome P450 superfamily.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 93 citations in OpenAlex.
- Supporting activities of cognate redox partners for sterol-metabolizing P450 enzymes in Mycobacterium neoaurum.The Journal of biological chemistry · 2026Article
- Efficient sex hormone biosensors in Saccharomyces cerevisiae cells to evaluate human aromatase activity and inhibition.Scientific reports · 2025Article
- Comprehensive Review on Plant Cytochrome P450 Evolution: Copy Number, Diversity, and Motif Analysis From Chlorophyta to Dicotyledoneae.Genome biology and evolution · 2024Review
- Decoding the Role of CYP450 Enzymes in Metabolism and Disease: A Comprehensive Review.Biomedicines · 2024Review
- Review of Eukaryote Cellular Membrane Lipid Composition, with Special Attention to the Fatty Acids.International journal of molecular sciences · 2023Review
- Dual factors required for cytochrome-P450-mediated hydrocarbon ring contraction in bacterial gibberellin phytohormone biosynthesis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis.Angewandte Chemie (International ed. in English) · 2023Article
- The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2023Article
- Hijacking Chemical Reactions of P450 Enzymes for Altered Chemical Reactions and Asymmetric Synthesis.International journal of molecular sciences · 2022Review
- Engineering medicinal plant-derived CYPs: a promising strategy for production of high-valued secondary metabolites.Planta · 2022Review
- Unravelling the role of transient redox partner complexes in P450 electron transfer mechanics.Scientific reports · 2022Article
- 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) induces ectopic calcification.Journal of clinical biochemistry and nutrition · 2022Article
- An Unprecedented Number of Cytochrome P450s Are Involved in Secondary Metabolism inMicroorganisms · 2022Article
- Functional expression and regulation of eukaryotic cytochrome P450 enzymes in surrogate microbial cell factories.Engineering microbiology · 2022Review
- Orphan cytochrome P450 20a1 CRISPR/Cas9 mutants and neurobehavioral phenotypes in zebrafish.Scientific reports · 2021Article
- RNA Sequencing Reveals Rice Genes Involved in Male Reproductive Development under Temperature Alteration.Plants (Basel, Switzerland) · 2021Article
- Cytochrome P450 Enzymes as Key Drivers of Alkaloid Chemical Diversification in Plants.Frontiers in plant science · 2021Review
- Molecular determinant of substrate binding and specificity of cytochrome P450 2J2.Scientific reports · 2020Article
- An overview of the factors playing a role in cytochrome P450 monooxygenase and ferredoxin interactions.Biophysical reviews · 2020Review
- Structural insight into the electron transfer pathway of a self-sufficient P450 monooxygenase.Nature communications · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
During the early years of cytochrome P450 research, a picture of conserved properties arose from studies of mammalian forms of these monooxygenases. They included the protohaem prosthetic group, the cysteine residue that coordinates to the haem iron and the reduced CO difference spectrum. Alternatively, the most variable feature of P450s was the enzymatic activities, which led to the conclusion that there are a large number of these enzymes, most of which have yet to be discovered. More recently, studies of these enzymes in other eukaryotes and in prokaryotes have led to the discovery of unexpected P450 properties. Many are variations of the original properties, whereas others are difficult to explain because of their unique nature relative to the rest of the known members of the superfamily. These novel properties expand our appreciation of the broad view of P450 structure and function, and generate curiosity concerning the evolution of P450s. In some cases, structural properties, previously not found in P450s, can lead to enzymatic activities impacting the biological function of organisms containing these enzymes; whereas, in other cases, the biological reason for the variations are not easily understood. Herein, we present particularly interesting examples in detail rather than cataloguing them all.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.