ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2013
Role of cytochrome P450s in insecticide resistance: impact on the control of mosquito-borne diseases and use of insecticides on Earth.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
179 citing papers in PubMed, 5 syntheses or guidelines pooled it, 409 citations in OpenAlex.
- Performance assessment of Bayesian meta-analytic predictive model on kdr mutation in insecticide-resistant malarial vectors in sub-Saharan Africa.Malaria journal · 2025Pooled it
- Insecticide resistance and the role of target-site insensitivity mutations among malaria vectors in China: A systematic review and meta-analysis.Parasites & vectors · 2025Pooled it
- Knockdown resistance (kdr) associated organochlorine resistance in mosquito-borne diseases (Culex quinquefasciatus): Systematic study of reviews and meta-analysis.PLoS neglected tropical diseases · 2024Pooled it
- Insecticide resistance of Dengue vectors in South East Asia: a systematic review.African health sciences · 2021Pooled it
- Dynamics and monitoring of insecticide resistance in malaria vectors across mainland Tanzania from 1997 to 2017: a systematic review.Malaria journal · 2019Pooled it
- Biopesticides as an eco-friendly approach to mosquitoes and their role in reducing transmission of vector-borne disease: updates and prospects.Pest management science · 2026Review
- Synthesis, Structure-Activity Considerations and Histopathological Effects of Diborane Derivatives as Mosquito Larvicides.Acta parasitologica · 2026Article
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- Multi-level assessment of chronic toxicity of the insect growth regulator lufenuron in the non-target aquatic organism Daphnia magna.Environmental geochemistry and health · 2026Article
- Pyrethroid-resistance in Anopheles gambiae s.l (Culicidae) populations from the Sudan Savannah ecoregion in Nigeria is partly mediated by knockdown mutation.BMC research notes · 2026Article
- Oviposition Deterrent and Larvicidal Activity ofTropical medicine and infectious disease · 2026Article
- Structural and evolutionary constraints of organophosphate resistance in dipteran carboxylesterases.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Metabolic resistance of the tiger mosquito to pyrethroid insecticides in La Réunion Island likely results from local adaptation.Genome biology and evolution · 2026Article
- Aedes albopictus gut symbiotic bacterium Bacillus cereus improves its deltamethrin resistance.Parasites & vectors · 2026Article
- Complex Roles of Insect Cytochrome P450s in Chemical Adaptation.International journal of biological sciences · 2026Review
- Physiological and Putative Organic Cation Transporter Expression Response to Alizarin Dye Exposure inInsects · 2025Article
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- Mechanisms of pyrethroid resistance in Culicidae mosquitoes from Hainan Island, China.Parasites & vectors · 2025Article
- Status and Mechanism of Insecticide Resistance in German Cockroach (Tropical life sciences research · 2025Review
119 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fight against diseases spread by mosquitoes and other insects has enormous environmental, economic and social consequences. Chemical insecticides remain the first line of defence but the control of diseases, especially malaria and dengue fever, is being increasingly undermined by insecticide resistance. Mosquitoes have a large repertoire of P450s (over 100 genes). By pinpointing the key enzymes associated with insecticide resistance we can begin to develop new tools to aid the implementation of control interventions and reduce their environmental impact on Earth. Recent technological advances are helping us to build a functional profile of the P450 determinants of insecticide metabolic resistance in mosquitoes. Alongside, the cross-responses of mosquito P450s to insecticides and pollutants are also being investigated. Such research will provide the means to produce diagnostic tools for early detection of P450s linked to resistance. It will also enable the design of new insecticides with optimized efficacy in different environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.