ArticleThe Journal of physiology2013
Short-term exercise training enhances functional sympatholysis through a nitric oxide-dependent mechanism.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Acute impact of inorganic nitrate supplementation after ischemia and during small muscle mass exercise in postmenopausal females: A pilot study.Physiological reports · 2024Trial
- The effect of sex on the isolated and combined α- and β-adrenergic control of blood flow during handgrip in adults at high altitude: An exploratory study.Physiological reports · 2026Article
- Neurocirculatory regulation and adaptations to exercise in chronic kidney disease.American journal of physiology. Heart and circulatory physiology · 2023Review
- Article
- The Impact of Training on the Loss of Cardiorespiratory Fitness in Aging Masters Endurance Athletes.International journal of environmental research and public health · 2022Review
- Does sympathetic vasoconstriction contribute to metabolism: Perfusion matching in exercising skeletal muscle?Frontiers in physiology · 2022Review
- Functional sympatholysis in mouse skeletal muscle involves sarcoplasmic reticulum swelling in arterial smooth muscle cells.Physiological reports · 2021Article
- Muscle metaboreflex adaptations to exercise training in health and disease.European journal of applied physiology · 2021Review
- Sympathetically mediated increases in cardiac output, not restraint of peripheral vasodilation, contribute to blood pressure maintenance during hyperinsulinemia.American journal of physiology. Heart and circulatory physiology · 2020Article
- Effect of acute dietary nitrate supplementation on sympathetic vasoconstriction at rest and during exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Nitric Oxide and Decreases in Resistance Exercise Blood Pressure With Aerobic Exercise Training in Older Individuals.Frontiers in physiology · 2019Article
- Aerobic Exercise Training Prevents Perivascular Adipose Tissue-Induced Endothelial Dysfunction in Thoracic Aorta of Obese Mice.Frontiers in physiology · 2019Article
- Increased endothelial shear stress improves insulin-stimulated vasodilatation in skeletal muscle.The Journal of physiology · 2019Article
- Evidence of a greater functional sympatholysis in habitually aerobic trained postmenopausal women.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Activity of muscle sympathetic neurons during normotensive pregnancy.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Sex differences in sympathetic vasoconstrictor responsiveness and sympatholysis.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Reduced blood flow to contracting skeletal muscle in ageing humans: is it all an effect of sand through the hourglass?The Journal of physiology · 2016Review
- Exercise training and α1-adrenoreceptor-mediated sympathetic vasoconstriction in resting and contracting skeletal muscle.Physiological reports · 2016Article
- Exercise training normalizes renal blood flow responses to acute hypoxia in experimental heart failure: role of the α1-adrenergic receptor.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Exercise training attenuates chemoreflex-mediated reductions of renal blood flow in heart failure.American journal of physiology. Heart and circulatory physiology · 2015Article
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Authors and funding
2 authors.
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Abstract
We tested the hypothesis that short-term mild- (M) and heavy-intensity (H) exercise training would enhance sympatholysis through a nitric oxide (NO)-dependent mechanism. Sprague-Dawley rats (n = 36) were randomly assigned to sedentary (S) or to M (20 m min(-1) 5% gradient) or H exercise training groups (40 m min(-1) 5% gradient). Rats assigned to M and H groups trained on 5 days week(-1) for 4 weeks, with the volume of training being matched between groups. Rats were anaesthetized and instrumented for stimulation of the lumbar sympathetic chain and the measurement of arterial blood pressure and femoral artery blood flow. The triceps surae muscle group was stimulated to contract rhythmically at 30 and 60% of maximal contractile force (MCF). The percentage change of femoral vascular conductance (%FVC) in response to sympathetic stimulation delivered at 2 and 5 Hz was determined at rest and during contraction at 30 and 60% MCF. The vascular response to sympathetic stimulation was reduced as a function of MCF in all rats (P < 0.05). At 30% MCF, the magnitude of sympatholysis (%FVC rest - contraction; %FVC) was greater in H compared with M and S groups (%FVC at 2 Hz, S, 9 ± 5; M, 11 ± 8; and H, 18 ± 7; and %FVC at 5 Hz, S, 6 ± 6; M, 12 ± 9; and H, 18 ± 7; P < 0.05) and was greater in H and M compared with S at 60% MCF (%FVC at 2 Hz, S, 15 ± 5; M, 25 ± 3; and H, 36 ± 6; and %FVC at 5 Hz, S, 22 ± 6; M, 33 ± 9; and H, 39 ± 9; P < 0.05). Blockade of NO synthase did not alter the magnitude of sympatholysis in S during contraction at 30 or 60% MCF. In contrast, NO synthase inhibition diminished sympatholysis in H at 30% MCF and in M and H at 60% MCF (P < 0.05). The present findings indicate that short-term exercise training augments sympatholysis in a training-intensity-dependent manner and through an NO-dependent mechanism.
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