ArticleMedical microbiology and immunology2013
Involvement of (IgG and IgM)-secreting B lymphocytes in severity of autoimmune hepatitis type 1.
Article in Medical microbiology and immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Exploratory Study of Autoantibody Profiling in Drug-Induced Liver Injury with an Autoimmune Phenotype.Hepatology communications · 2020Article
- B and T cells: (Still) the dominant orchestrators in autoimmune hepatitis.Autoimmunity reviewsReview
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
Autoimmune hepatitis type 1 (AIH1) is an autoimmune disease attacks the liver and characterized by periportal inflammation, elevated immunoglobulins, and autoantibodies. The central role of B lymphocyte in pathogenicity of AIH1 is unclear. Here, the effect of antibody-secreting cells activity in terms of number of plaque-forming cells (PFC) on severity of AIH1 was evaluated. The high number of PFC-(IgG and IgM) in peripheral blood of patients with AIH1 was observed and this was concomitant with increase in the number of CD4+ T lymphocyte, immunoglobulin (Ig) (IgG and IgM) concentrations, and levels of liver function tests (LFTs). However, the negative correlation (r < -0.5, P < 0.05) between the numbers of PFC-(IgG and IgM) and CD8+ T lymphocytes was reported here. The present study showed the positive relationship between the concentrations of Ig (IgG and IgM) and levels of LFTs (r > +0.5, P < 0.05). The high expression of IL-10 mRNA was found in the tissue culture of peripheral blood lymphocytes obtained from patients with AIH1 as compared with that isolated from control group (P < 0.05). The current study proved the direct role of (IgG and IgM)-secreting cells in severity of AIH1. This was associated with CD4+ cell numbers and IL-10 mRNA expression, and mediated by IgG and IgM.
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Registered trials
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