ArticleThe Journal of comparative neurology2013
GABAergic inputs from direct and indirect striatal projection neurons onto cholinergic interneurons in the primate putamen.
Article in The Journal of comparative neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 65 citations in OpenAlex.
- Article
- Enhanced motivated behavior mediated by pharmacological targeting of the FGF14/NaNature communications · 2025Article
- Extrinsic and intrinsic control of striatal cholinergic interneuron activity.Frontiers in molecular neuroscience · 2025Review
- Ultrastructural Localization of Glutamate Delta Receptor 1 in the Rodent and Primate Lateral Habenula.The Journal of comparative neurology · 2025Article
- Dynamic responses of striatal cholinergic interneurons control behavioral flexibility.Science advances · 2024Article
- Enhancing striatal acetylcholine facilitates dopamine release and striatal output in parkinsonian mice.Cell & bioscience · 2024Article
- Drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic neurons.Nature communications · 2023Article
- Electrophysiological characterization of the striatal cholinergic interneurons inDystonia (Lausanne, Switzerland) · 2022Article
- Input-specific control of interneuron numbers in nascent striatal networks.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Synaptic determinants of cholinergic interneurons hyperactivity during parkinsonism.Frontiers in synaptic neuroscience · 2022Article
- The role of carbonic anhydrase III and autophagy in type 2 diabetes with cardio-cerebrovascular disease.Metabolic brain disease · 2021Article
- Review
- Targeting the cholinergic system in Parkinson's disease.Acta pharmacologica Sinica · 2020Review
- Enhanced GABAergic Inhibition of Cholinergic Interneurons in the zQ175Frontiers in systems neuroscience · 2020Article
- Thalamic degeneration in MPTP-treated Parkinsonian monkeys: impact upon glutamatergic innervation of striatal cholinergic interneurons.Brain structure & function · 2019Article
- Temporal Coding of Reward Value in Monkey Ventral Striatal Tonically Active Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia.Neurobiology of disease · 2019Article
- Cholinergic modulation of striatal microcircuits.The European journal of neuroscience · 2019Review
- Striatal Cholinergic Interneurons: How to Elucidate Their Function in Health and Disease.Frontiers in pharmacology · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Striatal cholinergic interneurons (ChIs) are involved in reward-dependent learning and the regulation of attention. The activity of these neurons is modulated by intrinsic and extrinsic γ-aminobutyric acid (GABA)ergic and glutamatergic afferents, but the source and relative prevalence of these diverse regulatory inputs remain to be characterized. To address this issue, we performed a quantitative ultrastructural analysis of the GABAergic and glutamatergic innervation of ChIs in the postcommissural putamen of rhesus monkeys. Postembedding immunogold localization of GABA combined with peroxidase immunostaining for choline acetyltransferase showed that 60% of all synaptic inputs to ChIs originate from GABAergic terminals, whereas 21% are from putatively glutamatergic terminals that establish asymmetric synapses, and 19% from other (non-GABAergic) sources of symmetric synapses. Double pre-embedding immunoelectron microscopy using substance P and Met-/Leu-enkephalin antibodies to label GABAergic terminals from collaterals of "direct" and "indirect" striatal projection neurons, respectively, revealed that 47% of the indirect pathway terminals and 36% of the direct pathway terminals target ChIs. Together, substance P- and enkephalin-positive terminals represent 24% of all synapses onto ChIs in the monkey putamen. These findings show that ChIs receive prominent GABAergic inputs from multiple origins, including a significant contingent from axon collaterals of direct and indirect pathway projection neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.