Evidence map›Paper›PMID 23296531›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2013

Structural separations by ion mobility-MS for glycomics and glycoproteomics.

Larissa S Fenn, John A McLean

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. The Hitchhiker's guide to glycoproteomics.Biochemical Society transactions · 2021
    Review
  8. A Rapid Array-Based Approach toJournal of proteome research · 2019
    Article
  9. Glycosylation and its implications in breast cancer.Expert review of proteomics · 2019
    Review
  10. Review
  11. Article
  12. Article
  13. Isomer Information from Ion Mobility Separation of High-Mannose Glycan Fragments.Journal of the American Society for Mass Spectrometry · 2018
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Larissa S FennDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.
John A McLean

Funding

Structural Basis of Immune Recognition of Glycosylated AntigensU54GM062116 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SOBIESZCZUK, PETER · 2001 to 2010
$80.3M
New Methodologies for Accelerating Natural Product DiscoveryR01GM092218 · NIGMS · VANDERBILT UNIVERSITY · PI BACHMANN, BRIAN O, MCLEAN, JOHN ALAN · 2010 to 2018
$2.8M
Elucidation of Leukocyte and Macrophage Biomarker Signatures from Drugs of AbuseRC2DA028981 · NIDA · VANDERBILT UNIVERSITY · PI LIPSON, HOD, MCLEAN, JOHN ALAN · 2009 to 2010
$2.7M
NIDA NIH HHS RC2 DA028981NIDA NIH HHS RC2DA028981NIGMS NIH HHS 1R01GM092218-01NIGMS NIH HHS GM62116NIGMS NIH HHS R01 GM092218NIGMS NIH HHS U54 GM062116
6 · The paper itself

Abstract

This chapter describes the utility of ion mobility-mass spectrometry (IM-MS) for the detection and characterization of glycoproteins and associated glycoconjugates. IM-MS provides separations in two dimensions; one on the basis of molecular surface area or structure, and the other on molecular mass which creates the ability to differentiate biomolecular classes and isobaric species. When applied to the characterization of glycoproteins, IM-MS separates peptides from the associated glycans in the same digest without purification, and can also be used to separate different isomeric glycans which is a significant challenge in current glycomic studies. The chapter details the methodologies to use IM-MS for the study of glycans and glycoproteins for an audience ranging from new and potential practitioners to those already utilizing the technique.

Indexed as

Amino Acid SequenceGlycomicsGlycoproteinsMass SpectrometryMolecular Sequence DataPolysaccharidesProteomicsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationGlycoproteinsPolysaccharides

Identifiers

PMID23296531
PMCPMC5102027

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.