Evidence map›Paper›PMID 23296247›Full record

ReviewNature reviews. Gastroenterology & hepatology2013

Overlap of functional dyspepsia and GERD--diagnostic and treatment implications.

Eamonn M M Quigley, Brian E Lacy

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Gastroenterology & hepatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03282084 (A Prospective, Observational Study of the PPI Non-responder), which is not on this map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03282084 withdrawnnot on this mapstarted 2017, after this paper: background citation

A Prospective, Observational Study of the PPI Non-responder

TypeobservationalSponsorDartmouth-Hitchcock Medical CenterRan2017 to 2018Enrolled0ConditionsGastro Esophageal Reflux Disease PPI Non-RespondersArmsEGD with biopsy, EGD and impedance-pH study on PPI
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.

  1. Pooled it
  2. Gastric dysrhythmia in gastroesophageal reflux disease: a systematic review and meta-analysis.Esophagus : official journal of the Japan Esophageal Society · 2021
    Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Overlapping disorders of gut-brain interaction -More may not be so merry!Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025
    Article
  9. Dyspepsia-Is the Stomach Half Empty?Digestive diseases and sciences · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Association between Gastrointestinal Diseases and Migraine.International journal of environmental research and public health · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Eamonn M M QuigleyAlimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. e.quigley@ucc.ie
Brian E Lacy
Dartmouth–Hitchcock Medical Center · USUniversity College Cork · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GERD and functional dyspepsia are the two most prevalent upper gastrointestinal disorders. Gastro-oesophageal reflux is most commonly diagnosed using the cardinal symptoms of heartburn and regurgitation. Patients might also be diagnosed using a questionnaire, after empiric treatment with an acid suppressant, after upper endoscopy or by pH testing. Functional dyspepsia is best diagnosed using symptoms outlined by the Rome committee in conjunction with a normal upper endoscopy. Theoretically, distinguishing these two populations should be easy for all health-care providers. In reality, however, carefully separating out these two populations can be quite difficult, as substantial overlap exists epidemiologically, symptomatically and even diagnostically. This overlap renders precise diagnosis a challenge; given the limited treatment options, the primary goal is to identify those patients who will respond to acid suppressive therapy. Despite the frequency with which functional dyspepsia and GERD overlap, remarkably few studies have investigated this overlap. Most recommendations are based on data derived from separate studies of functional dyspepsia and GERD. A further limitation of existing studies is their failure to differentiate between the various diagnostic categories into which the individual presenting with heartburn might belong.

Indexed as

AntacidsAntidepressive Agents, TricyclicComorbidityDisease ManagementDyspepsiaGastroesophageal RefluxHistamine AntagonistsHumansPrevalenceAntacidsAntidepressive Agents, TricyclicHistamine Antagonists

Identifiers

PMID23296247
OpenAlexW2035518810

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.