ArticleNeuroImage2013
The hypnotic zolpidem increases the synchrony of BOLD signal fluctuations in widespread brain networks during a resting paradigm.
Article in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 55 citations in OpenAlex.
- Diazepam modulates hippocampal CA1 functional connectivity in people at clinical high-risk for psychosis.Psychological medicine · 2025Trial
- GABA concentrations in the anterior temporal lobe predict human semantic processing.Scientific reports · 2017Trial
- Disruption of cortical integration during midazolam-induced light sedation.Human brain mapping · 2015Trial
- Effects of seven-day diazepam administration on resting-state functional connectivity in healthy volunteers: a randomized, double-blind study.Psychopharmacology · 2015Trial
- An eight month randomized controlled exercise intervention alters resting state synchrony in overweight children.Neuroscience · 2014Trial
- Sleep deprivation exhibits an age-dependent effect on infraslow global brain activity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Monoamine Loss and Functional Connectivity Alterations in Patients With Parkinson's Disease and Depression.CNS neuroscience & therapeutics · 2025Article
- Thought contents during rest account for functional connectivity-behavior associations.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Decoupling Between Brain Activity and Cerebrospinal Fluid Movement in Neurological Disorders.Journal of magnetic resonance imaging : JMRI · 2024Review
- Mapping alterations in the local synchrony of the cerebral cortex in schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- Neurochemical and functional reorganization of the cognitive-ear link underlies cognitive impairment in presbycusis.NeuroImage · 2023Article
- Article
- Resting-state brain network in Parkinson's disease with different degrees of depression.Frontiers in neuroscience · 2022Article
- Brain Activity Fluctuations Propagate as Waves Traversing the Cortical Hierarchy.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Bioenergetics and abnormal functional connectivity in psychotic disorders.Molecular psychiatry · 2021Article
- Reduced coupling between cerebrospinal fluid flow and global brain activity is linked to Alzheimer disease-related pathology.PLoS biology · 2021Article
- Transient Arousal Modulations Contribute to Resting-State Functional Connectivity Changes Associated with Head Motion Parameters.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Time of day is associated with paradoxical reductions in global signal fluctuation and functional connectivity.PLoS biology · 2020Article
- Networks Are Associated With Depression in Patients With Parkinson's Disease: A Resting-State Imaging Study.Frontiers in neuroscience · 2020Article
- Vigilance Effects in Resting-State fMRI.Frontiers in neuroscience · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Networks of brain regions having synchronized fluctuations of the blood oxygen level-dependent functional magnetic resonance imaging (BOLD fMRI) time-series at rest, or "resting state networks" (RSNs), are emerging as a basis for understanding intrinsic brain activity. RSNs are topographically consistent with activity-related networks subserving sensory, motor, and cognitive processes, and studying their spontaneous fluctuations following acute drug challenge may provide a way to understand better the neuroanatomical substrates of drug action. The present within-subject double-blind study used BOLD fMRI at 3T to investigate the functional networks influenced by the non-benzodiazepine hypnotic zolpidem (Ambien). Zolpidem is a positive modulator of γ-aminobutyric acid(A) (GABA(A)) receptors, and engenders sedative effects that may be explained in part by how it modulates intrinsic brain activity. Healthy participants (n=12) underwent fMRI scanning 45 min after acute oral administration of zolpidem (0, 5, 10, or 20mg), and changes in BOLD signal were measured while participants gazed at a static fixation point (i.e., at rest). Data were analyzed using group independent component analysis (ICA) with dual regression and results indicated that compared to placebo, the highest dose of zolpidem increased functional connectivity within a number of sensory, motor, and limbic networks. These results are consistent with previous studies showing an increase in functional connectivity at rest following administration of the positive GABA(A) receptor modulators midazolam and alcohol, and suggest that investigating how zolpidem modulates intrinsic brain activity may have implications for understanding the etiology of its powerful sedative effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.