ArticleNeuroImage2013
Hippocampal shape variations at term equivalent age in very preterm infants compared with term controls: perinatal predictors and functional significance at age 7.
Article in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Advanced neuroimaging and its role in predicting neurodevelopmental outcomes in very preterm infants.Seminars in perinatology · 2016Pooled it
- Hippocampal growth and function are reduced in the newborn following fetal growth restriction.Brain : a journal of neurology · 2026Article
- Hippocampal malformation in Dravet syndrome.Epilepsia · 2026Review
- Adverse Childhood Experiences and Socioemotional Outcomes of Children Born Very Preterm.The Journal of pediatrics · 2025Article
- Predicting neurodevelopmental outcome in children born very preterm - does neonatal MRI have a role?Pediatric research · 2023Article
- Novel metrics to characterize temporal lobe of very preterm infants on term-equivalent brain MRI.Pediatric research · 2023Article
- Oestrogen treatment restores dentate gyrus development in premature newborns by IGF1 regulation.Journal of cellular and molecular medicine · 2023Article
- Associations of body composition with regional brain volumes and white matter microstructure in very preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2022Observational
- Structural and Functional Deviations of the Hippocampus in Schizophrenia and Schizophrenia Animal Models.International journal of molecular sciences · 2022Review
- Hippocampal epigenetic and insulin-like growth factor alterations in noninvasive versus invasive mechanical ventilation in preterm lambs.Pediatric research · 2021Article
- Hippocampal subfield volumes are nonspecifically reduced in premature-born adults.Human brain mapping · 2020Article
- Commentary - Marijuana use during pregnancy and premature birth: A problem likely to worsen.Journal of neonatal-perinatal medicine · 2020Article
- Biomechanical Forces Regulate Gene Transcription During Stretch-Mediated Growth of Mammalian Neurons.Frontiers in neuroscience · 2020Article
- Hippocampal alterations and functional correlates in adolescents and young adults with congenital heart disease.Human brain mapping · 2019Article
- A Novel Approach for Manual Segmentation of the Amygdala and Hippocampus in Neonate MRI.Frontiers in neuroscience · 2019Article
- Impaired hippocampal development and outcomes in very preterm infants with perinatal brain injury.NeuroImage. Clinical · 2019Observational
- Reduced hippocampal subfield volumes and memory function in school-aged children born preterm with very low birthweight (VLBW).NeuroImage. Clinical · 2019Article
- Annual Research Review: Not just a small adult brain: understanding later neurodevelopment through imaging the neonatal brain.Journal of child psychology and psychiatry, and allied disciplines · 2018Review
- Improving Long-Term Outcomes After Extracorporeal Membrane Oxygenation: From Observational Follow-Up Programs Toward Risk Stratification.Frontiers in pediatrics · 2018Review
- Prediction of cognitive and motor development in preterm children using exhaustive feature selection and cross-validation of near-term white matter microstructure.NeuroImage. Clinical · 2018Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 3 countries.
Funding
Abstract
The hippocampus undergoes rapid growth and development in the perinatal months. Infants born very preterm (VPT) are vulnerable to hippocampal alterations, and can provide a model of disturbed early hippocampal development. Hippocampal shape alterations have previously been associated with memory impairment, but have never been investigated in infants. The aims of this study were to determine hippocampal shape differences between 184 VPT infants (<30 weeks' gestation or <1250 g at birth) and 32 full-term infants, effects of perinatal factors, and associations between infant hippocampal shape and volume, and 7 year verbal and visual memory (California Verbal Learning Test - Children's Version and Dot Locations). Infants underwent 1.5 T magnetic resonance imaging at term equivalent age. Hippocampi were segmented, and spherical harmonics-point distribution model shape analysis was undertaken. VPT infants' hippocampi were less infolded than full-term infants, being less curved toward the midline and less arched superior-inferiorly. Straighter hippocampi were associated with white matter injury and postnatal corticosteroid exposure. There were no significant associations between infant hippocampal shape and 7 year memory measures. However, larger infant hippocampal volumes were associated with better verbal memory scores. Altered hippocampal shape in VPT infants at term equivalent age may reflect delayed or disrupted development. This study provides further insight into early hippocampal development and the nature of hippocampal abnormalities in prematurity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.