ArticleMolecular therapy : the journal of the American Society of Gene Therapy2013
Hyaluronan enhances bone marrow cell therapy for myocardial repair after infarction.
Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Injectable hydrogel-based combination therapy for myocardial infarction: a systematic review and Meta-analysis of preclinical trials.BMC cardiovascular disorders · 2024Pooled it
- Indirect 3D printing in tissue engineering: expanding materials used for improved scaffold functionality.Biomedical engineering online · 2025Review
- Control of the post-infarct immune microenvironment through biotherapeutic and biomaterial-based approaches.Drug delivery and translational research · 2023Review
- A deep dive into the darning effects of biomaterials in infarct myocardium: current advances and future perspectives.Heart failure reviews · 2022Review
- Epithelial-mesenchymal transition-related genes in coronary artery disease.Open medicine (Warsaw, Poland) · 2022Article
- Fibroblast contributions to ischemic cardiac remodeling.Cellular signalling · 2021Review
- Hyaluronate supports hESC-cardiomyocyte cell therapy for cardiac regeneration after acute myocardial infarction.Cell proliferation · 2020Article
- Tunable methacrylated hyaluronic acid-based hydrogels as scaffolds for soft tissue engineering applications.Journal of biomedical materials research. Part A · 2020Article
- Hyaluronic Acid Oligosaccharides Improve Myocardial Function Reconstruction and Angiogenesis against Myocardial Infarction by Regulation of Macrophages.Theranostics · 2019Article
- Linc-ROR Promotes Osteogenic Differentiation of Mesenchymal Stem Cells by Functioning as a Competing Endogenous RNA for miR-138 and miR-145.Molecular therapy. Nucleic acids · 2018Article
- Simultaneous Delivery of Wharton's Jelly Mesenchymal Stem Cells and Insulin-Like Growth Factor-1 in Acute Myocardial Infarction.Iranian journal of pharmaceutical research : IJPR · 2018Article
- Exogenous miR-29B Delivery Through a Hyaluronan-Based Injectable System Yields Functional Maintenance of the Infarcted Myocardium.Tissue engineering. Part A · 2018Article
- Cardiomyocyte proliferation in zebrafish and mammals: lessons for human disease.Cellular and molecular life sciences : CMLS · 2017Review
- Injection of Human Cord Blood Cells With Hyaluronan Improves Postinfarction Cardiac Repair in Pigs.Stem cells translational medicine · 2016Article
- In vivo experience with natural scaffolds for myocardial infarction: the times they are a-changin'.Stem cell research & therapy · 2015Review
- Human placenta-derived adherent cells improve cardiac performance in mice with chronic heart failure.Stem cells translational medicine · 2015Article
- Hyaluronan - a functional and structural sweet spot in the tissue microenvironment.Frontiers in immunology · 2015Review
- Article
- Hyaluronan and cardiac regeneration.Journal of biomedical science · 2014Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyaluronan (HA) has been shown to play an important role during early heart development and promote angiogenesis under various physiological and pathological conditions. In recent years, stem cell therapy, which may reduce cardiomyocyte apoptosis, increase neovascularization, and prevent cardiac fibrosis, has emerged as a promising approach to treat myocardial infarction (MI). However, effective delivery of stem cells for cardiac therapy remains a major challenge. In this study, we tested whether transplanting a combination of HA and allogeneic bone marrow mononuclear cells (MNCs) promotes cell therapy efficacy and thus improves cardiac performance after MI in rats. We showed that HA provided a favorable microenvironment for cell adhesion, proliferation, and vascular differentiation in MNC culture. Following MI in rats, compared with the injection of HA alone or MNC alone, injection of both HA and MNCs significantly reduced inflammatory cell infiltration, cardiomyocyte apoptosis, and infarct size and also improved cell retention, angiogenesis, and arteriogenesis, and thus the overall cardiac performance. Ultimately, HA/MNC treatment improved vasculature engraftment of transplanted cells in the infarcted region. Together, our results indicate that combining the biocompatible material HA with bone marrow stem cells exerts a therapeutic effect on heart repair and may further provide potential treatment for ischemic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.