ArticleClinics (Sao Paulo, Brazil)2012
Hypertonic saline solution reduces the inflammatory response in endotoxemic rats.
Article in Clinics (Sao Paulo, Brazil), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Leukocyte depletion during CPB: effects on inflammation and lung function.Inflammation · 2014Trial
- Disruption of macrophage cell volume drives inflammatory responses and type I interferon signaling.The Journal of cell biology · 2026Article
- Both lipopolysaccharide and vehicle treatments upregulate complement-dependent and complement-independent innate immune responses in Diamond-backed Watersnakes (Squamata:Frontiers in immunology · 2026Article
- Mitigating Post-Subarachnoid Hemorrhage Complications: Anti-Inflammatory and Anti-Apoptotic Effects of Anakinra in an Experimental Study.Journal of clinical medicine · 2025Article
- Preliminary investigation of a hypertonic saline nasal rinse as a hygienic intervention in dairy workers.Journal of occupational and environmental hygiene · 2023Article
- Neuroprotective effects of four different fluids on cerebral ischaemia/reperfusion injury in rats through stabilization of the blood-brain barrier.The European journal of neuroscience · 2021Article
- The Effects of Resuscitative Fluid Therapy on the Endothelial Surface Layer.Frontiers in veterinary science · 2021Review
- Crystalloid and Colloid Compositions and Their Impact.Frontiers in veterinary science · 2021Review
- LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation.eLife · 2020Article
- Hypertonic solution-induced preconditioning reduces inflammation and mortality rate.Journal of inflammation (London, England) · 2019Article
- Hypertonic saline and pentoxifylline enhance survival, reducing apoptosis and oxidative stress in a rat model of strangulated closed loop small bowel obstruction.Clinics (Sao Paulo, Brazil) · 2019Article
- Sodium lactate improves renal microvascular thrombosis compared to sodium bicarbonate and 0.9% NaCl in a porcine model of endotoxic shock: an experimental randomized open label controlled study.Annals of intensive care · 2018Article
- Hypertonic saline attenuates expression of Notch signaling and proinflammatory mediators in activated microglia in experimentally induced cerebral ischemia and hypoxic BV-2 microglia.BMC neuroscience · 2017Article
- Central GABAA receptors are involved in inflammatory and cardiovascular consequences of endotoxemia in conscious rats.Naunyn-Schmiedeberg's archives of pharmacology · 2016Article
- Amelioration of azoxymethane induced-carcinogenesis by reducing oxidative stress in rat colon by natural extracts.BMC complementary and alternative medicine · 2014Article
- Effects of crocin on spatial or aversive learning and memory impairments induced by lipopolysaccharide in rats.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveVolume replacement in septic patients improves hemodynamic stability. This effect can reduce the inflammatory response. The objective of this study was to evaluate the effect of 7.5% hypertonic saline solution versus 0.9% normal saline solution for volume replacement during an inflammatory response in endotoxemic rats.
methodsWe measured cytokines (serum and gut), nitrite, and lipid peroxidation (TBARS) as indicators of oxidative stress in the gut. Rats were divided into four groups: control group (C) that did not receive lipopolysaccharide; lipopolysaccharide injection without treatment (LPS); lipopolysaccharide injection with saline treatment (LPS +S); and lipopolysaccharide injection with hypertonic saline treatment (LPS +H). Serum and intestine were collected. Measurements were taken at 1.5, 8, and 24 h after lipopolysaccharide administration.
resultsOf the four groups, the LPS +H group had the highest survival rate. Hypertonic saline solution treatment led to lower levels of IL-6, IL-10, nitric oxide, and thiobarbituric acid reactive substances compared to 0.9% normal saline. In addition, hypertonic saline treatment resulted in a lower mortality compared to 0.9% normal saline treatment in endotoxemic rats. Volume replacement reduced levels of inflammatory mediators in the plasma and gut.
conclusionHypertonic saline treatment reduced mortality and lowered levels of inflammatory mediators in endotoxemic rats. Hypertonic saline also has the advantage of requiring less volume replacement.
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