ArticleBehavioural brain research2013
A history of chronic morphine exposure during adolescence increases despair-like behaviour and strain-dependently promotes sociability in abstinent adult mice.
Article in Behavioural brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Persistent effects of repeated adolescent and adult heroin vapor inhalation in female Wistar rats.Psychopharmacology · 2026Article
- A widespread internal brain state for fentanyl withdrawal.bioRxiv : the preprint server for biology · 2026Article
- Altered Pain, Emotion, and Stress in Adulthood: Neurobehavioral and Neuroendocrine Consequences of Adolescent Morphine Exposure.Basic and clinical neuroscience · 2025Article
- Article
- The influence of stress and early life adversity on addiction: Psychobiological mechanisms of risk and resilience.International review of neurobiology · 2020Review
- The future of rodent models in depression research.Nature reviews. Neuroscience · 2019Review
- Differential behavioral and molecular alterations upon protracted abstinence from cocaine versus morphine, nicotine, THC and alcohol.Addiction biology · 2017Article
- Long-lasting effects of adolescent oxycodone exposure on reward-related behavior and gene expression in mice.Psychopharmacology · 2016Article
- Substance use modulates stress reactivity: Behavioral and physiological outcomes.Physiology & behavior · 2016Review
- Dissociation of heroin-induced emotional dysfunction from psychomotor activation and physical dependence among inbred mouse strains.Psychopharmacology · 2015Article
- Distinct mu, delta, and kappa opioid receptor mechanisms underlie low sociability and depressive-like behaviors during heroin abstinence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- The kappa opioid receptor: from addiction to depression, and back.Frontiers in psychiatry · 2014Review
- The multiple facets of opioid receptor function: implications for addiction.Current opinion in neurobiology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
A crucial issue in treating opiate addiction, a chronic relapsing disorder, is to maintain a drug-free abstinent state. Prolonged abstinence associates with mood disorders, strongly contributing to relapse. In particular, substance use disorders occurring during adolescence predispose to depression later in adulthood. Using our established mouse model of opiate abstinence, we characterized emotional consequences into adulthood of morphine exposure during adolescence. Our results indicate that morphine treatment in adolescent mice has no effect on anxiety-like behaviours in adult mice, after abstinence. In contrast, morphine treatment during adolescence increases behavioural despair in adult mice. We also show that morphine exposure strain-dependently enhances sociability in adult mice. Additional research will be required to understand where and how morphine acts during brain maturation to affect emotional and social behaviours into adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.