ArticleThe Journal of cell biology2013
Compression and dilation of the membrane-cortex layer generates rapid changes in cell shape.
Article in The Journal of cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 62 citations in OpenAlex.
- Drosophila embryo cellularization is tuned by the viscoelastic properties of membrane-cortex linkers.Biophysical journal · 2026Article
- Follow the flow: Actin and membrane act as an integrated system to globally coordinate cell shape and movement.Current opinion in cell biology · 2024Review
- Changes in cell surface excess are coordinated with protrusion dynamics during 3D motility.Biophysical journal · 2023Article
- Celebrating the creative scientific life of Ken Jacobson.Biophysical journal · 2023Article
- Crawling, waving, inch worming, dilating, and pivoting mechanics of migrating cells: Lessons from Ken Jacobson.Biophysical journal · 2023Review
- Curved crease origami and topological singularities at a cellular scale enable hyper-extensibility ofbioRxiv : the preprint server for biology · 2023Article
- Article
- From pattern to process? Dual travelling waves, with contrasting propagation speeds, best describe a self-organised spatio-temporal pattern in population growth of a cyclic rodent.Ecology letters · 2022Article
- Recent progress in the mechanistic understanding of NET formation in neutrophils.The FEBS journal · 2022Review
- Cortical softening elicits zygotic contractility during mouse preimplantation development.PLoS biology · 2022Article
- Compromised Biomechanical Properties, Cell-Cell Adhesion and Nanotubes Communication in Cardiac Fibroblasts Carrying the Lamin A/C D192G Mutation.International journal of molecular sciences · 2021Article
- Basigin Associates with Integrin in Order to Regulate Perineurial Glia andThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Cell spread area and traction forces determine myosin-II-based cortex thickness regulation.Biochimica et biophysica acta. Molecular cell research · 2019Article
- Going with the Flow (or Not).Biophysical journal · 2019Article
- Excitable RhoA dynamics drive pulsed contractions in the earlyThe Journal of cell biology · 2018Article
- Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations.Developmental cell · 2017Article
- Turnover and flow of the cell membrane for cell migration.Scientific reports · 2017Article
- Leishmania infection inhibits macrophage motility by altering F-actin dynamics and the expression of adhesion complex proteins.Cellular microbiology · 2017Article
- Membrane Supply and Demand Regulates F-Actin in a Cell Surface Reservoir.Developmental cell · 2016Article
- Cell Surface Mechanochemistry and the Determinants of Bleb Formation, Healing, and Travel Velocity.Biophysical journal · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Rapid changes in cellular morphology require a cell body that is highly flexible yet retains sufficient strength to maintain structural integrity. We present a mechanism that meets both of these requirements. We demonstrate that compression (folding) and subsequent dilation (unfolding) of the coupled plasma membrane-cortex layer generates rapid shape transformations in rounded cells. Two- and three-dimensional live-cell images showed that the cyclic process of membrane-cortex compression and dilation resulted in a traveling wave of cortical actin density. We also demonstrate that the membrane-cortex traveling wave led to amoeboid-like cell migration. The compression-dilation hypothesis offers a mechanism for large-scale cell shape transformations that is complementary to blebbing, where the plasma membrane detaches from the actin cortex and is initially unsupported when the bleb extends as a result of cytosolic pressure. Our findings provide insight into the mechanisms that drive the rapid morphological changes that occur in many physiological contexts, such as amoeboid migration and cytokinesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.