ArticleVirology journal2013
Temporal changes in respiratory adenovirus serotypes circulating in the greater Toronto area, Ontario, during December 2008 to April 2010.
Article in Virology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- A rapid and highly sensitive multiple detection of human adenovirus type 3, type 7 and respiratory syncytial virus by recombinase-aided reverse transcription PCR.Journal of clinical laboratory analysis · 2023Article
- Human Mastadenovirus Infections in Children: A Review of the Current Status in the Arab World in the Middle East and North Africa.Children (Basel, Switzerland) · 2022Review
- Nonreplicating Adenoviral Vectors: Improving Tropism and Delivery of Cancer Gene Therapy.Cancers · 2021Review
- Development of Rapid and Visual Nucleic Acid Detection Methods towards Four Serotypes of Human Adenovirus Species B Based on RPA-LF Test.BioMed research international · 2021Article
- Development and evaluation of recombinase-aided amplification assays incorporating competitive internal controls for detection of human adenovirus serotypes 3 and 7.Virology journal · 2019Article
- Human adenovirus in nasopharyngeal and blood samples from children with and without respiratory tract infections.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2019Article
- Molecular characterization of human adenovirus associated with acute respiratory infections in Cameroon from 2011 to 2014.Virology journal · 2018Article
- Circulation of HAdV-41 with diverse genome types and recombination in acute gastroenteritis among children in Shanghai.Scientific reports · 2017Article
- Respiratory viruses in patients with influenza-like illness in Senegal: Focus on human respiratory adenoviruses.PloS one · 2017Article
- Human Adenovirus Associated with Severe Respiratory Infection, Oregon, USA, 2013-2014.Emerging infectious diseases · 2016Article
- Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCertain adenovirus serotypes cause severe infections, especially in children. It is important to monitor temporal changes in serotypes causing clinical disease. The objective of this study was to document circulating respiratory adenovirus serotypes by sequencing adenovirus culture isolates from the Greater Toronto Area, Ontario, during December 2008 to April 2010.
methodsNucleic acid extraction was performed on 90 respiratory tract adenovirus culture isolates. PCR amplification was conducted with primers targeting the adenovirus hexon gene hypervariable region 7. Sanger sequencing and phylogenetic analyses were performed to determine serotype identities.
resultsAmong 90 clinical respiratory isolates sequenced, eight different serotypes were identified. Serotype 3 (34, 38%), serotype 2 (30, 30%), and serotype 1 (14, 16%) isolates were most common; serotypes 5, 6, 11, 17 and 21 were also observed. Seventeen (50%) of the 34 HAdV-3 isolates were identified between December 2008 and February 2009, while none were identified from December 2009 to February 2010. Between December 2008 and April 2009, the two most common serotypes were HAdV-3 and HAdV-2, detected in 18 (53%) and 8 (24%) of the 34 cultures isolates, respectively. However, from December 2009 to April 2010, there was an increase in HAdV-2, which became the most prevalent serotype, detected in 10 (50%) of the 20 isolates identified (p = 0.05).
conclusionsThere was a gradual shift in prevailing adenovirus serotypes during the 17 month study period, from predominantly HAdV-3 to HAdV-2. If an adenovirus vaccine were to be broadly implemented, multiple serotypes should be included.
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