Trial reportJournal of the American Association for Laboratory Animal Science : JAALAS2012
A therapeutic dose of ketoprofen causes acute gastrointestinal bleeding, erosions, and ulcers in rats.
Trial report in Journal of the American Association for Laboratory Animal Science : JAALAS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Gelatin-Based Microspheres for Sustained Ketoprofen Delivery in Difficult-to-Heal Wounds.Polymers · 2026Article
- Large animal models for cardiac remuscularization studies: A methodological review.Frontiers in cardiovascular medicine · 2023Review
- Effects of Buprenorphine and Carprofen on Appetite in New Zealand White Rabbits (Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- A Review of Long-acting Parenteral Analgesics for Mice and Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Review
- Evaluation of histophysiological alterations associated with ketoprofen administration in albino NMRI mice.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Letter to the Editor.Comparative medicine · 2020Article
- A Review of the Effects of Pain and Analgesia on Immune System Function and Inflammation: Relevance for Preclinical Studies.Comparative medicine · 2019Review
- Article
- Methamphetamine-Induced Brain Injury and Alcohol Drinking.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2018Article
- Efficacy of Common Analgesics for Postsurgical Pain in Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2016Article
- Analgesic Efficacy of Firocoxib, a Selective Inhibitor of Cyclooxygenase 2, in a Mouse Model of Incisional Pain.Journal of the American Association for Laboratory Animal Science : JAALAS · 2015Article
- Pharmacological evaluation and preparation of nonsteroidal anti-inflammatory drugs containing an N-acyl hydrazone subunit.International journal of molecular sciences · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perioperative treatment of several rats in our facility with ketoprofen (5 mg/kg SC) resulted in blood loss, peritonitis, and death within a day to a little more than a week after surgery that was not related to the gastrointestinal tract. Published reports have established the 5-mg/kg dose as safe and effective for rats. Because ketoprofen is a nonselective nonsteroidal antiinflammatory drug that can damage the gastrointestinal tract, the putative diagnosis for these morbidities and mortalities was gastrointestinal toxicity caused by ketoprofen (5 mg/kg). We conducted a prospective study evaluating the effect of this therapeutic dose of ketoprofen on the rat gastrointestinal tract within 24 h. Ketoprofen (5 mg/kg SC) was administered to one group of rats that then received gas anesthesia for 30 min and to another group without subsequent anesthesia. A third group was injected with saline followed by 30 min of gas anesthesia. Our primary hypothesis was that noteworthy gastrointestinal bleeding and lesions would occur in both groups treated with ketoprofen but not in rats that received saline and anesthesia. Our results showed marked gastrointestinal bleeding, erosions, and small intestinal ulcers in the ketoprofen-treated rats and minimal damages in the saline-treated group. The combination of ketoprofen and anesthesia resulted in worse clinical signs than did ketoprofen alone. We conclude that a single 5-mg/kg dose of ketoprofen causes acute mucosal damage to the rat small intestine.
Indexed as
Identifiers
23294892PMC3508190W1524996761What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.