ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2012
Resistance of Sprague-Dawley Rats to infection with Helicobacter pullorum.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Helicobacter pullorum is an enterohepatic Helicobacter spp. known to infect both chickens and humans. H. pullorum infection has recently been reported in both mice and rats. This study was designed to determine whether standard methods of colony health surveillance using exposure to rodent soiled bedding could detect H. pullorum in Sprague-Dawley rats. We exposed 8 Helicobacter-free Sprague-Dawley rats to bedding from H. pullorum-infected Brown Norway rats. Fecal samples were analyzed by PCR every 2 wk for 22 wk. Dirty bedding transfer resulted in intermittent positive fecal PCR results; however, none of the rats became persistently infected with H. pullorum. Select intestinal tissues collected at necropsy analyzed by PCR were negative for H. pullorum. To determine whether the failure to detect H. pullorum in Sprague-Dawley rats receiving contact bedding was due to resistance of Sprague-Dawley rats to H. pullorum colonization, 10 Helicobacter-free Sprague-Dawley rats were orally dosed with H. pullorum. Fecal samples were analyzed by PCR every 2 wk for 12 wk. At 2 wk after infection, 5 of 10 rats were PCR positive for H. pullorum. By 12 wpi, only 2 rats were persistently colonized with H. pullorum according to culture and PCR results. These data contrast with our previous data, which showed a high frequency of both natural and experimental H. pullorum infection in Brown Norway rats. Sprague-Dawley rats are resistant to experimentally induced H. pullorum gastrointestinal colonization when dosed orally with H. pullorum or exposed to bedding from H. pullorum-infected rats.
Indexed as
Identifiers
23294887PMC3508185W115819877What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.