ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2012
Transmission of mouse parvovirus to neonatal mice.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Efficacy of Soiled Bedding Transfer for Transmission of Mouse and Rat Infections to Sentinels: A Systematic Review.PloS one · 2016Pooled it
- Evaluation of Sentinel-Free Soiled Bedding as a Replacement for Direct Sampling in PCR Detection of Rodent Pathogens during Quarantine.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8.Nature communications · 2023Article
- Confirmation of Pathogen 'Burnout' in Mouse Colonies with Previous Evidence of Infection with Parvovirus and Rotavirus.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- The Impact of Age and Sex on Mouse Models of Melioidosis.Pathogens (Basel, Switzerland) · 2020Article
- Results of Survey Regarding Prevalence of Adventitial Infections in Mice and Rats at Biomedical Research Facilities.Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- Effect of immunodeficiency on MPV shedding and transmission.Journal of the American Association for Laboratory Animal Science : JAALAS · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the infection of newborn mice with mouse parvovirus (MPV), a single MPV-infected mouse was added to each of 15 cages, each of which housed an uninfected breeding pair of Swiss Webster mice just before parturition. Seven litters were left with their parents, and the remaining 8 litters were fostered at postpartum day 1. All dams were shedding MPV at 1 and 2 wk after exposure. Soiled-bedding transmission did not differ between cages with and without litters. Half the foster dams but none of the fostered pups seroconverted to MPV. None of the pups left with their birth mothers had MPV DNA in their feces at 3 or 6 wk after exposure, but pups in 6 of 7 litters were MPV seropositive at 6 wk. To investigate MPV infection of older neonatal mice, 9 dams with 7-d-old litters and 9 dams with 14-d-old litters each were exposed to an MPV-infected mouse. At weaning, pups exposed to MPV at 7 or 14 d of age were shedding MPV and were seronegative but became seropositive by 6 wk of age and transmitted the infection to sentinels. In conclusion, fostering of pups had no benefit and may spread infection because the pups may act as fomites, infecting the foster dam. Infection of 7- or 14-d-old mice likely occurred because maternal antibodies had not been transferred to the progeny before they began to ingest MPV-laden feces.
Indexed as
Identifiers
23294886PMC3508184W1509493330What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.