ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2012
Rats housed on corncob bedding show less slow-wave sleep.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Analysis of IVC Microenvironments During an Extended Cage-Change Interval in Rats (Rattus norvegicus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Impact of Bedding Volume on Cage Microclimate and Behavior in 129SV and Desmin-Knockout (Des-/-) Mice.Animals : an open access journal from MDPI · 2026Article
- Beyond Comfort: A Review of the Critical Role of Bedding Selection in Rodent Welfare, Microenvironment, and Research Reproducibility.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Review
- Enhancing Rodent Welfare, Cost Savings, and Efficiency: Implementation and Review of Data-Driven Improvements.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Review
- Breeding fat-tailed dunnarts (Sminthopsis crassicaudata) in captivity: Revised practices to minimize stress whilst maintaining considerations of wild biology.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- Bedding as a variable affecting fasting blood glucose and vascular physiology in mice.American journal of physiology. Heart and circulatory physiology · 2023Article
- Rapid ammonia build-up in small individually ventilated mouse cages cannot be overcome by adjusting the amount of bedding.Lab animal · 2023Article
- Identification of Rodent Husbandry Refinement Opportunities through Benchmarking and Collaboration.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Evaluation of Potential Sustainable Bedding Substrates Focusing on Preference, Behavior, and Stress Physiology in Rats-A Pilot Study.Animals : an open access journal from MDPI · 2021Article
- Comparative Effects of 1/4-inch and 1/8-inch Corncob Bedding on Cage Ammonia Levels, Behavior, and Respiratory Pathology of Male C57BL/6 and 129S1/Svlm Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Compressed Paper as an Alternative to Corn Cob Bedding in Mouse (Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Review
- Environment shapes sleep patterns in a wild nocturnal primate.Scientific reports · 2019Article
- Sleeping through anything: The effects of unpredictable disruptions on mouse sleep, healing, and affect.PloS one · 2019Article
- Article
- Introducing Therioepistemology: the study of how knowledge is gained from animal research.Lab animal · 2017Review
- Feasibility of Using Rice Hulls as Bedding for Laboratory Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2016Article
- Comparison of growth and pubertal progression in wild type female rats with different bedding types.Annals of pediatric endocrinology & metabolism · 2015Article
- Rapid effects of estrogens on behavior: environmental modulation and molecular mechanisms.Frontiers in neuroendocrinology · 2014Review
- Effect of Corncob bedding on feed conversion efficiency in a high-fat diet-induced prediabetic model in C57Bl/6J mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the reported advantages of corncob bedding, questions have emerged about how comfortable animals find this type of bedding as a resting surface. In this study, encephalography (EEG) was used to compare the effects of corncob and aspen-chip bedding on rat slow-wave sleep (SWS). According to a facility-wide initiative, rats that were weaned on aspen-chip bedding were switched to corncob bedding in home cages and EEG recording chambers. Spontaneous EEG recordings obtained for 5 wk after the switch to corncob bedding demonstrated that rats spent significantly less time in SWS as compared with levels measured on aspen chips just prior to the bedding switch. SWS remained low even after a 5-wk acclimation period to the corncob bedding. We then acutely switched back to aspen-chip bedding in EEG recording chambers. Acute reinstatement of aspen-chip bedding during EEG recording was associated with an average 22% increase in time spent in SWS, with overall levels of SWS comparable to the levels measured on aspen chips prior to the change to corncob bedding. Aspen-chip bedding subsequently was reinstated in both home cages and EEG recording chambers, and SWS baseline levels were restored. These data raise important concerns about the effects of corncob bedding on rodents used in research.
Indexed as
Identifiers
23294881PMC3508179W2344384392What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.