ArticleEpilepsia2013
Evidence for a shared genetic susceptibility to migraine and epilepsy.
Article in Epilepsia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis.The journal of headache and pain · 2020Pooled it
- The effects of transcutaneous auricular vagus nerve stimulation in epilepsy comorbid with migraine on the EEG power spectrum: a randomized controlled trial.Frontiers in neurology · 2025Article
- A cross-sectional, multicenter survey of the prevalence and influencing factors for migraine in epilepsy.Epilepsia open · 2024Article
- A comparison of comorbid headache between patients with temporal lobe epilepsy and juvenile myoclonic epilepsy.Scientific reports · 2023Article
- Epilepsy and the gut: Perpetrator or victim?World journal of gastrointestinal pathophysiology · 2022Review
- Action Potentials Are Critical for the Propagation of Focally Elicited Spreading Depolarizations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Headache in people with epilepsy.Nature reviews. Neurology · 2021Review
- Decreased content of ascorbic acid (vitamin C) in the brain of knockout mouse models of Na+,K+-ATPase-related neurologic disorders.PloS one · 2021Article
- Decreased Resting-State Functional Connectivity of Periaqueductal Gray in Temporal Lobe Epilepsy Comorbid With Migraine.Frontiers in neurology · 2021Article
- The comorbidity of headaches in pediatric epilepsy patients: How common and what types?Neurosciences (Riyadh, Saudi Arabia) · 2019Article
- Painful Seizures: a Review of Epileptic Ictal Pain.Current pain and headache reports · 2019Review
- Review
- Studies on the Mechanism of Glutamate Metabolism in NTG-Induced Migraine Rats Treated with DCXF.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Relationship between right-to-left shunt and migraine in patients with epilepsy: a single-centre, cross-sectional study in China.BMJ open · 2018Article
- [Pain and epilepsy : A clinical, neuroanatomical and pathophysiological review].Schmerz (Berlin, Germany) · 2018Article
- Epilepsy and migraine-Are they comorbidity?Genes & diseases · 2018Review
- Clinical observation of the effect of prophylaxis on allodynia in patients with migraine.Journal of pain research · 2018Article
- A systematic approach for identifying shared mechanisms in epilepsy and its comorbidities.Database : the journal of biological databases and curation · 2018Article
- Headache and Epilepsy.Journal of epilepsy research · 2017Review
- Shared mechanisms of epilepsy, migraine and affective disorders.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeAlthough epilepsy and migraine are known to co-occur within individuals, the contribution of a shared genetic susceptibility to this comorbidity remains unclear. We investigated the hypothesis of shared genetic effects on migraine and epilepsy in the Epilepsy Phenome/Genome Project (EPGP) cohort.
methodsWe studied prevalence of a history of migraine in 730 EPGP participants aged ≥ 12 years with nonacquired focal epilepsy (NAFE) or generalized epilepsy (GE) from 501 families containing two or more individuals with epilepsy of unknown cause. Information on migraine without aura (MO) and migraine with aura (MA) was collected using an instrument validated for individuals ≥ 12 years. Because many individuals have both MO and MA, we considered two nonoverlapping groups of individuals with migraine: those who met criteria for MA in any of their headaches (MA), and those who did not ("MO-only"). EPGP participants were interviewed about the history of seizure disorders in additional nonenrolled family members. We evaluated associations of migraine prevalence in enrolled subjects with a family history of seizure disorders in additional nonenrolled relatives, using generalized estimating equations to control for the nonindependence of observations within families. KEY
findingsPrevalence of a history of MA (but not MO-only) was significantly increased in enrolled participants with two or more additional affected first-degree relatives. SIGNIFICANCE: These findings support the hypothesis of a shared genetic susceptibility to epilepsy and MA.
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Registered trials
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