Evidence map›Paper›PMID 23294202›Full record

ReviewMolecular pharmaceutics2013

Dendrimer nanoscaffolds for potential theranostics of prostate cancer with a focus on radiochemistry.

Su-Tang Lo, Amit Kumar, Jer-Tsong Hsieh, Xiankai Sun

Abstract readReview
In one paragraph

Review in Molecular pharmaceutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Dendrimers-based Hydrogels and Nanogels for Drug Delivery.Current pharmaceutical biotechnology · 2026
    Review
  2. Article
  3. Recent advancements in nanoparticles for cancer treatment.Medical oncology (Northwood, London, England) · 2025
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. A Glimpse into Dendrimers Integration in Cancer Imaging and Theranostics.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. NCs-Delivered Pesticides: A Promising Candidate in Smart Agriculture.International journal of molecular sciences · 2021
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Su-Tang LoDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Amit Kumar
Jer-Tsong Hsieh
Xiankai Sun

Funding

Targeting aggressive prostate cancer with novel theranostic nanomedicineR01CA159144 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HSIEH, JER-TSONG · 2011 to 2015
$1.6M
NCI NIH HHS R01 CA159144NCI NIH HHS R01CA159144
6 · The paper itself

Abstract

Dendrimers are a class of structurally defined macromolecules featured with a central core, a low-density interior formed by repetitive branching units, and a high-density exterior terminated with surface functional groups. In contrast to their polymeric counterparts, dendrimers are nanosized and symmetrically shaped, which can be reproducibly synthesized on a large scale with monodispersity. These unique features have made dendrimers of increasing interest for drug delivery and other biomedical applications as nanoscaffold systems. Intended to address the potential use of dendrimers for the development of theranostic agents, which combines therapeutics and diagnostics in a single entity for personalized medicine, this review focuses on the reported methodologies of using dendrimer nanoscaffolds for targeted imaging and therapy of prostate cancer. Of particular interest, relevant chemistry strategies are discussed due to their important roles in the design and synthesis of diagnostic and therapeutic dendrimer-based nanoconjugates and potential theranostic agents, targeted or nontargeted. Given the developing status of nanoscaffolded theranostics, major challenges and potential hurdles are discussed along with the examples representing current advances.

Indexed as

DendrimersDrug Delivery SystemsHumansMaleProstatic NeoplasmsRadiochemistryDendrimers

Identifiers

PMID23294202
PMCPMC3599782

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.