ArticleEpilepsia2013
The relationship between the localization of the generalized spike and wave discharge generators and the response to valproate.
Article in Epilepsia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 55 citations in OpenAlex.
- Gray matter density alterations in idiopathic generalized epilepsy patients: a double inversion recovery Magnetic Resonance Imaging study.Acta epileptologica · 2026Article
- Structural and functional connectivity associations with anterior cingulate sulcal variability.Brain structure & function · 2024Article
- Article
- Structural and functional connectivity associations with anterior cingulate sulcal variability.Research square · 2024Article
- Comparison of Resting-State EEG Network Analyses With and Without Parallel MRI in Genetic Generalized Epilepsy.Brain topography · 2023Article
- Review
- EEG Markers of Treatment Resistance in Idiopathic Generalized Epilepsy: From Standard EEG Findings to Advanced Signal Analysis.Biomedicines · 2022Review
- Revisiting the Morphology and Classification of the Paracingulate Gyrus with Commentaries on Ambiguous Cases.Brain sciences · 2021Article
- Recent Advances in Neuroimaging of Epilepsy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Pretreatment Source Location and Functional Connectivity Network Correlated With Therapy Response in Childhood Absence Epilepsy: A Magnetoencephalography Study.Frontiers in neurology · 2021Article
- The Effect of Anti-seizure Medications on the Propagation of Epileptic Activity: A Review.Frontiers in neurology · 2021Review
- Distinct Topographical Patterns of Spike-Wave Discharge in Transgenic and Pharmacologically Induced Absence Seizure Models.Experimental neurobiology · 2019Article
- Pharmaco-fMRI: A Tool to Predict the Response to Antiepileptic Drugs in Epilepsy.Frontiers in neurology · 2019Review
- Abnormalities of diffusional kurtosis imaging and regional homogeneity in idiopathic generalized epilepsy with generalized tonic-clonic seizures.Experimental and therapeutic medicine · 2019Article
- Effects of carbamazepine and lamotrigine on functional magnetic resonance imaging cognitive networks.Epilepsia · 2018Article
- Recent advances in epilepsy.Journal of neurology · 2017Review
- Can we predict drug response by volumes of the corpus callosum in newly diagnosed focal epilepsy?Brain and behavior · 2017Observational
- Neuroimaging in Epilepsy.Current neurology and neuroscience reports · 2017Review
- White Matter Abnormalities in Patients with Treatment-Resistant Genetic Generalized Epilepsies.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Methods and utility of EEG-fMRI in epilepsy.Quantitative imaging in medicine and surgery · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeUp to 30% of patients with idiopathic generalized epilepsy (IGE) have seizures that are refractory to medication despite appropriate therapy that commonly includes valproate (VPA). The aim of this study was to compare patients with VPA-refractory and VPA-responsive IGE in order to determine whether there are group differences in generalized spike and wave discharge (GSWD) generators that may be associated with VPA resistance.
methodsOf 89 IGE patients who underwent electroencephalography (EEG) combined with functional magnetic resonance imaging (fMRI; EEG/fMRI), 25 with GSWDs identified in EEG/fMRI data were included. Simultaneous acquisition of 64 channels of EEG data at 10 kHz was performed using an MRI-compatible EEG cap and amplifier at 4T. VPA resistance was defined as lack of seizure control despite therapeutic dose of VPA. KEY
findingsThe fMRI blood oxygen-level dependent (BOLD) correlates of GSWD in the entire group involved midline thalamus, frontal regions comprising Brodmann areas 6, 24, and 32, and temporal lobes diffusely. When VPA-responsive and VPA-resistant patients were compared, BOLD signal increases were noted in the VPA-resistant patients in medial frontal cortex, along the paracingulate gyrus (Montreal Neurological Institute; MNI x = 2, y = 13.6, z = 45.9), and anterior insula bilaterally (right MNI x = 37.6, y = 7.8, z = 0.6, left MNI x = -35.3, y = 13.6, z = -5.3). SIGNIFICANCE: Our findings support the hypothesis that VPA-resistant and VPA-responsive patients may have different GSWD generators. Furthermore, we hypothesize that these differences in GSWD generators may be the reason for different responses to VPA.
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Registered trials
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