ArticleEpilepsia2013
Reduced default mode network connectivity in treatment-resistant idiopathic generalized epilepsy.
Article in Epilepsia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Voxel-wise Functional Connectivity of the Default Mode Network in Epilepsies: A Systematic Review and Meta-Analysis.Current neuropharmacology · 2022Pooled it
- Negative BOLD response to interictal discharges in epilepsy using intracranial EEG-fMRI.Neuroimage. Reports · 2026Article
- Long-term efficacy of anterior nucleus of the thalamus deep brain stimulation in drug-resistant epilepsy: a 5-year multicenter study.BMC medicine · 2025Article
- Article
- Brain connectivity correlates of breathing and cardiac patterns in epilepsy: A study including SUDEP cases.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Editorial: Advances in epilepsy research: exploring biomarkers, brain stimulation, and neurosurgical interventions.Frontiers in human neuroscience · 2025Article
- Power Spectral Density and Default Mode Network Connectivity in Generalized Epilepsy Syndromes: What to Expect from Drug-Resistant Patients.Biomedicines · 2024Article
- Creativity and its link to epilepsy.Epilepsia open · 2024Review
- Diffusion tensor imaging for detecting biomarkers of idiopathic epilepsy in dogs.Frontiers in veterinary science · 2024Review
- Resting-state functional MRI study of conventional MRI-negative intractable epilepsy in children.Frontiers in human neuroscience · 2024Article
- Review
- Deep learning resting state functional magnetic resonance imaging lateralization of temporal lobe epilepsy.Epilepsia · 2022Article
- Alterations of Cerebral Perfusion and Functional Connectivity in Children With Idiopathic Generalized Epilepsy.Frontiers in neuroscience · 2022Article
- Regional and remote connectivity patterns in focal extratemporal lobe epilepsy.Annals of translational medicine · 2021Article
- Recent Advances in Neuroimaging of Epilepsy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Cortico-striato-thalamo-cerebellar networks of structural covariance underlying different epilepsy syndromes associated with generalized tonic-clonic seizures.Human brain mapping · 2021Article
- Functional network topology in drug resistant and well-controlled idiopathic generalized epilepsy: a resting state functional MRI study.Brain communications · 2021Article
- Pretreatment Source Location and Functional Connectivity Network Correlated With Therapy Response in Childhood Absence Epilepsy: A Magnetoencephalography Study.Frontiers in neurology · 2021Article
- Frequency-specific changes in the default mode network in patients with cingulate gyrus epilepsy.Human brain mapping · 2020Article
- Abnormal directed connectivity of resting state networks in focal epilepsy.NeuroImage. Clinical · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeIdiopathic generalized epilepsy (IGE) resistant to treatment is common, but its neuronal correlates are not entirely understood. Therefore, the aim of this study was to examine resting-state default mode network (DMN) functional connectivity in patients with treatment-resistant IGE.
methodsTreatment resistance was defined as continuing seizures despite an adequate dose of valproic acid (valproate, VPA). Data from 60 epilepsy patients and 38 healthy controls who underwent simultaneous electroencephalography (EEG) and resting-state functional magnetic resonance imaging (fMRI) were included (EEG/fMRI). Independent component analysis (ICA) and dual regression were used to quantify DMN connectivity. Confirmatory analysis using seed-based voxel correlation was performed. KEY
findingsThere was a significant reduction of DMN connectivity in patients with treatment-resistant epilepsy when compared to patients who were treatment responsive and healthy controls. Connectivity was negatively correlated with duration of epilepsy. SIGNIFICANCE: Our findings in this large sample of patients with IGE indicate the presence of reduced DMN connectivity in IGE and show that connectivity is further reduced in treatment-resistant epilepsy. DMN connectivity may be useful as a biomarker for treatment resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.