ArticleWorld journal of gastrointestinal pathophysiology2012
Endothelin and neonatal capsaicin regulate gastric resistance to injury in BDL rats.
Article in World journal of gastrointestinal pathophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 6 citations in OpenAlex.
- Mechanism of Weiwei granules in the treatment of chronic activeHistology and histopathology · 2024Trial
- Nitric oxide released from luminal s-nitroso-N-acetylcysteine increases gastric mucosal blood flow.Molecules (Basel, Switzerland) · 2015Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
aimTo investigate the relationship between primary afferent neurons, endothelin (ET) and the role of its receptors on ethanol-induced gastric damage in cirrhotic rats.
methodsCirrhosis and portal hypertension were induced in rats by bile duct ligation (BDL) while controls had a sham operation. The association between ET and afferent neurons on the gastric mucosa was evaluated by capsaicin treatment in newborn rats, the use of ET agonists or antagonists, gastric ET-1 and -3 mRNA and synthetic capacity. Ethanol-induced damage was assessed using ex vivo gastric chamber experiments. Gastric blood flow was measured by laser-Doppler flowmetry.
resultsET-3 and an ET(B) receptor antagonist significantly reduced the extent of ethanol-induced gastric damage in BDL rats. Gastric ET-1 and -3 levels were 30% higher in BDL rats compared to control rats. Capsaicin treatment restored the gastric resistance and blood flow responses to topical application of ethanol in BDL rats and ET-1 and -3 production to levels observed in controls.
conclusionOur results suggest that the reduced resistance of the gastric mucosa of cirrhotic rats to ethanol-induced injury is a phenomenon modulated by ET through the ET(B) receptor and by sensory afferent neurons.
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