ArticleScientific reports2013
Axonal trafficking of an antisense RNA transcribed from a pseudogene is regulated by classical conditioning.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- miRNA-1175 downregulates a long non-coding natural antisense RNA and promotes long term memory.Scientific reports · 2025Article
- Fear extinction is regulated by the activity of long noncoding RNAs at the synapse.Nature communications · 2023Article
- Integration of RNA-seq and ATAC-seq analyzes the effect of low dose neutron-γ radiation on gene expression of lymphocytes from oilfield logging workers.Frontiers in chemistry · 2023Article
- Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation.Scientific reports · 2021Article
- Article
- A CREB2-targeting microRNA is required for long-term memory after single-trial learning.Scientific reports · 2018Article
- The temporal expression profile of a Nos3-related natural antisense RNA in the brain suggests a possible role in neurogenesis.Nitric oxide : biology and chemistry · 2017Article
- RetrogeneDB-a database of plant and animal retrocopies.Database : the journal of biological databases and curation · 2017Article
- A novel long non-coding natural antisense RNA is a negative regulator of Nos1 gene expression.Scientific reports · 2015Article
- Characterization of human pseudogene-derived non-coding RNAs for functional potential.PloS one · 2014Article
- Asymmetric localization of natural antisense RNA of neuropeptide sensorin in Aplysia sensory neurons during aging and activity.Frontiers in genetics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Natural antisense transcripts (NATs) are endogenous RNA molecules that are complementary to known RNA transcripts. The functional significance of NATs is poorly understood, but their prevalence in the CNS suggests a role in brain function. Here we investigated a long NAT (antiNOS-2 RNA) associated with the regulation of nitric oxide (NO) production in the CNS of Lymnaea, an established model for molecular analysis of learning and memory. We show the antiNOS-2 RNA is axonally trafficked and demonstrate that this is regulated by classical conditioning. Critically, a single conditioning trial changes the amount of antiNOS-2 RNA transported along the axon. This occurs within the critical time window when neurotransmitter NO is required for memory formation. Our data suggest a role for the antiNOS-2 RNA in establishing memories through the regulation of NO signaling at the synapse.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.