ArticleFood digestion2012
Development of the Digestive System-Experimental Challenges and Approaches of Infant Lipid Digestion.
Article in Food digestion, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 115 citations in OpenAlex.
- Digestive Responses to Fortified Cow or Goat Dairy Drinks: A Randomised Controlled Trial.Nutrients · 2018Trial
- Infant milk fat droplet size and coating affect postprandial responses in healthy adult men: a proof-of-concept study.European journal of clinical nutrition · 2017Trial
- SN2-Palmitate Reduces Fatty Acid Excretion in Chinese Formula-fed Infants.Journal of pediatric gastroenterology and nutrition · 2016Trial
- Transient remodeling of gut metabolism supports juvenile growth and adult fitness in Drosophila.Nature communications · 2026Article
- The Gut in Early Life-Postnatal Challenges.Children (Basel, Switzerland) · 2026Review
- Polyphenols in the Central Nervous System: Cellular Effects and Liposomal Delivery Approaches.International journal of molecular sciences · 2025Review
- Human milkFrontiers in nutrition · 2025Review
- Peroxisomes during postnatal development of mouse endocrine and exocrine pancreas display cell-type- and stage-specific protein composition.Cell and tissue research · 2023Article
- Roles of Milk Fat Globule Membrane on Fat Digestion and Infant Nutrition.Food science of animal resources · 2022Review
- Preparation of Human Milk Fat Substitutes: A Review.Life (Basel, Switzerland) · 2022Review
- Review
- Effect of Formulation Variables on the Stability of a Live, Rotavirus (RV3-BB) Vaccine Candidate using in vitro Gastric Digestion Models to Mimic Oral Delivery.Journal of pharmaceutical sciences · 2021Article
- Digestion and Absorption of Milk Phospholipids in Newborns and Adults.Frontiers in nutrition · 2021Review
- Beneficial Effect of Mildly Pasteurized Whey Protein on Intestinal Integrity and Innate Defense in Preterm and Near-Term Piglets.Nutrients · 2020Article
- In Vitro Digestion of Human Milk: Influence of the Lactation Stage on the Micellar Carotenoids Content.Antioxidants (Basel, Switzerland) · 2019Article
- Compositional Dynamics of the Milk Fat Globule and Its Role in Infant Development.Frontiers in pediatrics · 2018Review
- Milk Fat Globule Membrane Supplementation in Formula Modulates the Neonatal Gut Microbiome and Normalizes Intestinal Development.Scientific reports · 2017Article
- Milk fat globule membrane coating of large lipid droplets in the diet of young mice prevents body fat accumulation in adulthood.The British journal of nutrition · 2016Article
- An interactomics overview of the human and bovine milk proteome over lactation.Proteome science · 2016Article
- The Gut Microbiota as a Therapeutic Target in IBD and Metabolic Disease: A Role for the Bile Acid Receptors FXR and TGR5.Microorganisms · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At least during the first 6 months after birth, the nutrition of infants should ideally consist of human milk which provides 40-60 % of energy from lipids. Beyond energy, human milk also delivers lipids with a specific functionality, such as essential fatty acids (FA), phospholipids, and cholesterol. Healthy development, especially of the nervous and digestive systems, depends fundamentally on these. Epidemiological data suggest that human milk provides unique health benefits during early infancy that extend to long-lasting benefits. Preclinical findings show that qualitative changes in dietary lipids, i.e., lipid structure and FA composition, during early life may contribute to the reported long-term effects. Little is known in this respect about the development of digestive function and the digestion and absorption of lipids by the newborn. This review gives a detailed overview of the distinct functionalities that dietary lipids from human milk and infant formula provide and the profound differences in the physiology and biochemistry of lipid digestion between infants and adults. Fundamental mechanisms of infant lipid digestion can, however, almost exclusively be elucidated in vitro. Experimental approaches and their challenges are reviewed in depth.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.