ArticleDevelopment (Cambridge, England)2013
Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed.
- Staged Construction of Pluripotent Stem Cell Lung Models for Assessing Respiratory Toxicity of Environmental Pollutants.Environment & health (Washington, D.C.) · 2025Review
- Acquisition of neural fate by combination of BMP blockade and chromatin modification.iScience · 2023Article
- Plpp3, a novel regulator of pluripotency exit and endodermal differentiation of mouse embryonic stem cells.Biology open · 2023Article
- Rapid and robust directed differentiation of mouse epiblast stem cells into definitive endoderm and forebrain organoids.Development (Cambridge, England) · 2022Article
- Bioactive hydrogel microcapsules for guiding stem cell fate decisions by release and reloading of growth factors.Bioactive materials · 2022Article
- Temporal transcriptomic profiling reveals dynamic changes in gene expression of Xenopus animal cap upon activin treatment.Scientific reports · 2021Article
- Arginine methylation of METTL14 promotes RNA NNature communications · 2021Article
- A Stem Cell Approach to Cure Type 1 Diabetes.Cold Spring Harbor perspectives in biology · 2021Review
- Article
- Intestinal Organoids Generated from Human Pluripotent Stem Cells.JMA journal · 2020Review
- Transcriptionally dynamic progenitor populations organised around a stable niche drive axial patterning.Development (Cambridge, England) · 2019Article
- Hydrocortisone Promotes Differentiation of Mouse Embryonic Stem Cell-Derived Definitive Endoderm toward Lung Alveolar Epithelial Cells.Cell journal · 2019Article
- Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program.Nature neuroscience · 2018Article
- Demethylation of induced pluripotent stem cells from type 1 diabetic patients enhances differentiation into functional pancreatic β cells.The Journal of biological chemistry · 2017Article
- Late stage definitive endodermal differentiation can be defined by Daf1 expression.BMC developmental biology · 2016Article
- Microfluidic fabrication of bioactive microgels for rapid formation and enhanced differentiation of stem cell spheroids.Acta biomaterialia · 2016Article
- PTF1a Activity in Enriched Posterior Foregut Endoderm, but Not Definitive Endoderm, Leads to Enhanced Pancreatic Differentiation in an In Vitro Mouse ESC-Based Model.Stem cells international · 2016Article
- Editing genetics, stem cells are prophetic, what's the best way to model cells of diabetics?Stem cell investigation · 2016Article
- A loss-of-function and H2B-Venus transcriptional reporter allele for Gata6 in mice.BMC developmental biology · 2015Article
- Generating human intestinal tissues from pluripotent stem cells to study development and disease.The EMBO journal · 2015Review
Corrections and comments
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5 authors.
Funding
Abstract
Embryonic stem (ES) cells hold great promise with respect to their potential to be differentiated into desired cell types. Of interest are organs derived from the definitive endoderm, such as the pancreas and liver, and animal studies have revealed an essential role for Nodal in development of the definitive endoderm. Activin A is a related TGFβ member that acts through many of the same downstream signaling effectors as Nodal and is thought to mimic Nodal activity. Detailed characterization of ES cell-derived endodermal cell types by gene expression analysis in vitro and functional analysis in vivo reveal that, despite their similarity in gene expression, Nodal and Activin-derived endodermal cells exhibit a distinct difference in functional competence following transplantation into the developing mouse embryo. Pdx1-expressing cells arising from the respective endoderm populations exhibit extended differences in their competence to mature into insulin/c-peptide-expressing cells in vivo. Our findings underscore the importance of functional cell-type evaluation during stepwise differentiation of stem cells.
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