ArticleMedical oncology (Northwood, London, England)2013
Leptomeningeal metastases from genitourinary cancer: the University of Texas MD Anderson Cancer Center experience.
Article in Medical oncology (Northwood, London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 54 citations in OpenAlex.
- Risk factors for leptomeningeal carcinomatosis in patients with brain metastases who have previously undergone stereotactic radiosurgery.Journal of neuro-oncology · 2014Trial
- Brain and Spinal Leptomeningeal Metastases in Prostate Cancer Detected by PSMA PET and MRI Fusion.Clinical nuclear medicine · 2026Article
- Leptomeningeal metastasis from large-cell neuroendocrine carcinoma of the cervix: a case report and literature review.Frontiers in oncology · 2026Article
- Meningeal mass revealing undifferentiated renal carcinoma: A case report.Urology case reports · 2025Article
- Beyond the brain: exploring the impact of animal models of leptomeningeal disease from solid tumors.Acta neuropathologica communications · 2025Review
- Isolated Leptomeningeal Carcinomatosis in Urothelial Carcinoma: A Case Report of Positive CSF Cytology With Negative Imaging.Case reports in oncological medicine · 2025Article
- Leptomeningeal metastases in prostate cancer: A review of the current literature.Current urology · 2024Article
- A case report of prostate cancer with leptomeningeal metastasis and bone marrow involvement.Cancer reports (Hoboken, N.J.) · 2024Article
- Case report: Two cases of leptomeningeal metastases in patients with metastatic urothelial carcinoma treated with enfortumab vedotin.Frontiers in oncology · 2024Article
- Carcinomatous meningitis from ovarian serous carcinoma: A case report.Oncology letters · 2023Article
- Visual loss as the initial manifestation of an ignored disseminated prostate cancer: A case report.American journal of ophthalmology case reports · 2022Article
- A case report of prostate cancer with leptomeningeal metastasis.Cancer reports (Hoboken, N.J.) · 2022Article
- Clinical Problem Solving: A 56-Year-Old Woman With Right Facial Weakness, Numbness, and Diplopia.The Neurohospitalist · 2022Article
- Prolonged Survival and Restored Useful Life by Early Induction of Intrathecal Chemotherapy in a Patient with Leptomeningeal Carcinomatosis from Ovarian Cancer.Brain sciences · 2022Article
- A case report of prostate adenocarcinoma with leptomeningeal carcinomatosis and intracerebral metastasis.Clinical case reports · 2021Article
- A case report of endometrial adenocarcinoma with leptomeningeal metastases.Clinical case reports · 2021Article
- Dural spread from metastatic prostate cancer.BMJ case reports · 2021Article
- Leptomeningeal Carcinomatosis of a Poorly Differentiated Cervical Carcinoma Caused by Human Papillomavirus Type 18.Viruses · 2021Article
- Leptomeningeal Carcinomatosis in Urothelial Carcinoma of the Urinary Bladder: A Report of a Patient with a Fulminant Course Who Died of Cancer after Definitive Therapies.Case reports in urology · 2021Article
- Central Nervous System Metastasis in Patients With Urothelial Carcinoma: Institutional Experience and a Comprehensive Review of the Literature.Clinical genitourinary cancer · 2020Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptomeningeal metastasis (LM) most commonly arise from breast and lung cancers, and melanoma. Genitourinary cancer (including ovarian, prostate, uterine kidney and bladder) rarely cause LM, with only case reports published. The aims of the study were to describe cases of patients with Genitourinary cancer and Leptomeningeal metastasis, to estimate its prevalence and describe its behavior and outcome. We queried the MD Anderson database for patients with LM and genitourinary cancer between 1978 and 2011. The files of all patients with genitourinary cancer and leptomeningeal disease were retrospectively reviewed. Out of 93960 GU cancer patients treated in MD Anderson (cervix cancer 13,289, ovarian cancer 13,126, bladder cancer 11,834, prostate cancer 41,830, and kidney 13,881), 31 cases (0.03 %) of GU cancer with LM were identified in MD Anderson Cancer Center (MDACC) between 1978 and 2011. Eight patients had bladder cancer, 4 had cervical cancer, 4 had renal cancer, 8 had ovarian cancer and 7 had prostate cancer. Mean age of diagnosis of cancer was 55.9 ± 11.7 (range 20-74). Mean time from primary diagnosis to LM diagnosis was 141.46 ± 244 weeks (range 0.43-409.57). Median survival after LM diagnosis was 15.7 weeks (range 0.85-142.57). The patients presented with multiple signs and symptoms. Although rare-LM should be considered as a complication of GU cancer. Awareness of early neurological signs and symptoms may help the clinician to make an early diagnosis and possibly intervene to prevent neurological deficits.
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