Evidence map›Paper›PMID 23292753›Full record

ArticleChembiochem : a European journal of chemical biology2013

Fluorescent live-cell imaging of metabolically incorporated unnatural cyclopropene-mannosamine derivatives.

Christian M Cole, Jun Yang, Jolita Šečkutė, Neal K Devaraj

Abstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Aluminum-[EJNMMI radiopharmacy and chemistry · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Bioorthogonal chemistry.Nature reviews. Methods primers · 2021
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Lipidated cyclopropenesTetrahedron letters · 2018
    Article
  16. The Future of Bioorthogonal Chemistry.ACS central science · 2018
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christian M Cole *Department of Chemistry and Biochemistry University of California, San Diego 9500 Gilman Dr, La Jolla, CA 92093 (USA).
Jun Yang *Department of Chemistry and Biochemistry University of California, San Diego 9500 Gilman Dr, La Jolla, CA 92093 (USA).
Jolita ŠečkutėDepartment of Chemistry and Biochemistry University of California, San Diego 9500 Gilman Dr, La Jolla, CA 92093 (USA).
Neal K DevarajDepartment of Chemistry and Biochemistry University of California, San Diego 9500 Gilman Dr, La Jolla, CA 92093 (USA).

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Fast in vivo CLICK chemistries for PET imagingK01EB010078 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEVARAJ, NEAL KRISHNA · 2010 to 2014
$852k
NIBIB NIH HHS K01 EB010078NIBIB NIH HHS K01EB010078NIGMS NIH HHS P50 GM085763NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

Sugar coated: We recently developed methylcyclopropenes as low-molecular-weight tetrazine coupling partners. Here, we demonstrate that methylcyclopropenes can meet the stringent steric demands required for metabolic imaging of unnatural mannosamines on live cells. Using sequential azide-alkyne chemistry, we also demonstrate multicolor imaging of two different metabolically incorporated unnatural sugars.

Indexed as

AlkynesAzidesCell LineCell SurvivalClick ChemistryCycloaddition ReactionCyclopropanesFluorescent DyesHexosaminesHumansMicroscopy, ConfocalAlkynesAzidesCyclopropanescyclopropeneFluorescent DyesHexosaminesmannosamine

Identifiers

PMID23292753
PMCPMC4010072

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.