ArticleThe Plant cell2013
Repression of essential chloroplast genes reveals new signaling pathways and regulatory feedback loops in chlamydomonas.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 114 citations in OpenAlex.
- VIA1 is a conserved regulator of thylakoid membrane integrity that acts through VIPP1.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications.Chemical reviews · 2026Review
- Article
- Integrating Morphology and Chloroplast Genomics: A New East Asian Species ofEcology and evolution · 2026Article
- Hidden diversity: Transcriptomic and photosynthetic variation among common 'wild type' Chlamydomonas strains.The Plant journal : for cell and molecular biology · 2025Article
- A modular high-throughput approach for advancing synthetic biology in the chloroplast of Chlamydomonas.Nature plants · 2025Article
- Regulation of nucleus-encoded trans-acting factors allows orthogonal fine-tuning of multiple transgenes in the chloroplast of Chlamydomonas reinhardtii.Plant biotechnology journal · 2025Article
- Molecular phylogeny and comparative chloroplast genome analysis of the type species Crucigenia quadrata.BMC plant biology · 2025Article
- The role of the pigment-protein complex LHCBM1 in nonphotochemical quenching in Chlamydomonas reinhardtii.Plant physiology · 2024Article
- Comparison of organelle genomes between endangered mangrove plantFrontiers in plant science · 2024Article
- Article
- An RNA thermometer in the chloroplast genome of Chlamydomonas facilitates temperature-controlled gene expression.Nucleic acids research · 2023Article
- Proteomic characterization of a lutein-hyperaccumulating Chlamydomonas reinhardtii mutant reveals photoprotection-related factors as targets for increasing cellular carotenoid content.Biotechnology for biofuels and bioproducts · 2023Article
- Comparative chloroplast genomics reveals the phylogeny and the adaptive evolution of Begonia in China.BMC genomics · 2023Article
- Chloroplast protein import machinery and quality control.The FEBS journal · 2022Review
- The plastid-encoded protein Orf2971 is required for protein translocation and chloroplast quality control.The Plant cell · 2022Article
- Comparative chloroplast genome analyses ofFrontiers in plant science · 2022Article
- Molecular origins of induction and loss of photoinhibition-related energy dissipation qScience advances · 2021Article
- Chlamydomonas proteases: classification, phylogeny, and molecular mechanisms.Journal of experimental botany · 2021Article
- Exploring the Impact of Terminators on Transgene Expression inLife (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although reverse genetics has been used to elucidate the function of numerous chloroplast proteins, the characterization of essential plastid genes and their role in chloroplast biogenesis and cell survival has not yet been achieved. Therefore, we developed a robust repressible chloroplast gene expression system in the unicellular alga Chlamydomonas reinhardtii based mainly on a vitamin-repressible riboswitch, and we used this system to study the role of two essential chloroplast genes: ribosomal protein S12 (rps12), encoding a plastid ribosomal protein, and rpoA, encoding the α-subunit of chloroplast bacterial-like RNA polymerase. Repression of either of these two genes leads to the arrest of cell growth, and it induces a response that involves changes in expression of nuclear genes implicated in chloroplast biogenesis, protein turnover, and stress. This response also leads to the overaccumulation of several plastid transcripts and reveals the existence of multiple negative regulatory feedback loops in the chloroplast gene circuitry.
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