ArticleNature neuroscience2013
In vivo reprogramming of circuit connectivity in postmitotic neocortical neurons.
Article in Nature neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
104 citing papers in PubMed, 185 citations in OpenAlex.
- Direct neuronal reprogramming: emerging therapeutic strategies for neurodegenerative disorders.Annals of medicine · 2026Review
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- Mitochondria and its epigenetic dynamics: Insight into synaptic regulation and synaptopathies.Functional & integrative genomics · 2025Review
- A perfect recipe for a corticospinal neuron.eLife · 2024Article
- SIMS: A deep-learning label transfer tool for single-cell RNA sequencing analysis.Cell genomics · 2024Article
- Unraveling Neuronal Identities Using SIMS: A Deep Learning Label Transfer Tool for Single-Cell RNA Sequencing Analysis.bioRxiv : the preprint server for biology · 2023Article
- Thalamocortical control of cell-type specificity drives circuits for processing whisker-related information in mouse barrel cortex.Nature communications · 2023Article
- Tle4 controls both developmental acquisition and early post-natal maturation of corticothalamic projection neuron identity.Cell reports · 2023Article
- Lmo4 synergizes with Fezf2 to promote direct in vivo reprogramming of upper layer cortical neurons and cortical glia towards deep-layer neuron identities.PLoS biology · 2023Article
- A Spacetime Odyssey of Neural Progenitors to Generate Neuronal Diversity.Neuroscience bulletin · 2023Review
- Neuroplasticity related to chronic pain and its modulation by microglia.Inflammation and regeneration · 2022Review
- Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency.eLife · 2022Article
- miR-137 and miR-122, two outer subventricular zone non-coding RNAs, regulate basal progenitor expansion and neuronal differentiation.Cell reports · 2022Article
- Transcription factor 4 controls positioning of cortical projection neurons through regulation of cell adhesion.Molecular psychiatry · 2021Article
- Uncovering Statistical Links Between Gene Expression and Structural Connectivity Patterns in the Mouse Brain.Neuroinformatics · 2021Article
- Postmitotic Prox1 Expression Controls the Final Specification of Cortical VIP Interneuron Subtypes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Review
- Transcriptional repression by FEZF2 restricts alternative identities of cortical projection neurons.Cell reports · 2021Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular mechanisms that control how progenitors generate distinct subtypes of neurons, and how undifferentiated neurons acquire their specific identity during corticogenesis, are increasingly understood. However, whether postmitotic neurons can change their identity at late stages of differentiation remains unknown. To study this question, we developed an electrochemical in vivo gene delivery method to rapidly manipulate gene expression specifically in postmitotic neurons. Using this approach, we found that the molecular identity, morphology, physiology and functional input-output connectivity of layer 4 mouse spiny neurons could be specifically reprogrammed during the first postnatal week by ectopic expression of the layer 5B output neuron-specific transcription factor Fezf2. These findings reveal a high degree of plasticity in the identity of postmitotic neocortical neurons and provide a proof of principle for postnatal re-engineering of specific neural microcircuits in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.