ArticleJournal of biomedical optics2013
Dual-tracer background subtraction approach for fluorescent molecular tomography.
Article in Journal of biomedical optics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
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- Reconstruction based on adaptive group least angle regression for fluorescence molecular tomography.Biomedical optics express · 2023Article
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- Fluorescent Imaging forProceedings of SPIE--the International Society for Optical Engineering · 2020Article
- Intracellular paired agent imaging enables improved evaluation of tyrosine kinase inhibitor target engagement.Proceedings of SPIE--the International Society for Optical Engineering · 2020Article
- Paired-agent imaging for detection of head and neck cancers.Proceedings of SPIE--the International Society for Optical Engineering · 2019Article
- Simultaneous extracellular and intracellular quantification of EGFR using paired-agent imaging in anProceedings of SPIE--the International Society for Optical Engineering · 2019Article
- A thermo-sensitive fluorescent agent based method for excitation light leakage rejection for fluorescence molecular tomography.Physics in medicine and biology · 2019Article
- Ratiometric optical nanoprobes enable accurate molecular detection and imaging.Chemical Society reviews · 2018Review
- Quantitative in vivo cell-surface receptor imaging in oncology: kinetic modeling and paired-agent principles from nuclear medicine and optical imaging.Physics in medicine and biology · 2015Review
- Macroscopic-imaging technique for subsurface quantification of near-infrared markers during surgery.Journal of biomedical optics · 2015Article
- Tomography of epidermal growth factor receptor binding to fluorescent Affibody in vivo studied with magnetic resonance guided fluorescence recovery in varying orthotopic glioma sizes.Journal of biomedical optics · 2015Article
- Quantitative in vivo immunohistochemistry of epidermal growth factor receptor using a receptor concentration imaging approach.Cancer research · 2014Article
- Towards non-invasive characterization of breast cancer and cancer metabolism with diffuse optics.PET clinics · 2013Article
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Authors and funding
8 authors.
Funding
Abstract
Diffuse fluorescence tomography requires high contrast-to-background ratios to accurately reconstruct inclusions of interest. This is a problem when imaging the uptake of fluorescently labeled molecularly targeted tracers in tissue, which can result in high levels of heterogeneously distributed background uptake. We present a dual-tracer background subtraction approach, wherein signal from the uptake of an untargeted tracer is subtracted from targeted tracer signal prior to image reconstruction, resulting in maps of targeted tracer binding. The approach is demonstrated in simulations, a phantom study, and in a mouse glioma imaging study, demonstrating substantial improvement over conventional and homogenous background subtraction image reconstruction approaches.
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